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The Effects of Statin Therapy on Oxidized Ldl and Its Antibodies: A Systematic Review and Meta-Analysis Publisher Pubmed



Jamialahmadi T1 ; Baratzadeh F2 ; Reiner Z3 ; Mannarino MR4 ; Cardenia V5 ; Simentalmendia LE6 ; Pirro M4 ; Watts GF7 ; Sahebkar A8, 9, 10
Authors
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Authors Affiliations
  1. 1. Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Department of Clinical Pharmacy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Internal Medicine, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia
  4. 4. Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, Italy
  5. 5. Department of Agricultural, Forest and Food Sciences (DISAFA), University of Turin, Grugliasco, 10095, Italy
  6. 6. Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico
  7. 7. Cardiometabolic Service, Department of Cardiology, Royal Perth Hospital, School of Medicine, The University of Western Australia, Perth, WA, Australia
  8. 8. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  10. 10. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Oxidative Medicine and Cellular Longevity Published:2022


Abstract

Background. Elevated serum low-density lipoproteins (LDL), the substrate for the formation of atherogenic oxidized LDLs (oxLDL), are a causal factor for atherosclerotic cardiovascular disease (ASCVD). Statins are well known to decrease LDL particle concentration and reduce ASCVD morbidity and mortality. Objective. To perform a meta-analysis of the effects of statins (i.e., type, dose, and duration of treatment) on serum levels of oxLDL and on immunoglobulin M (IgM) and immunoglobulin G (IgG) antibody levels against oxLDL. Methods. PubMed, Scopus, Embase, and Web of Science were searched up to February 5th, 2021, for randomized controlled trials (RCT) evaluating the effect of statins on oxLDL and anti-oxLDL antibody levels. Meta-analysis was performed using Comprehensive Meta-Analysis (CMA) V2 software. To evaluate the influence of each study on the overall effect size, a sensitivity analysis was performed using the leave-one-out method. Evaluation of the funnel plot, Begg's rank correlation, and Egger's weighted regression tests was used to assess the presence of publication bias in the meta-analysis. Results. A total of 28 RCTs including 4019 subjects were finally included in the meta-analysis. The results indicated a significant decrease in circulating concentrations of oxLDL after treatment with statins (SMD: -2.150, 95% CI: -2.640, -1.697, p<0.001). Subgroup analysis found no significant effect of the intensity of statin treatment or statin lipophilicity on the reduction of circulating concentrations of oxLDL. An additional meta-analysis of 3 trials showed that statins did not change the serum levels of IgM and IgG antibodies to oxLDL. Conclusion. Statin therapy decreases serum oxLDL concentrations but does not affect circulating levels of anti-oxLDL antibodies. © 2022 Tannaz Jamialahmadi et al.
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