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Short-Term Effect of High-Dose Vitamin D on the Level of Interleukin 10 in Patients With Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Publisher Pubmed



Ashtari F1 ; Toghianifar N2 ; Zarkeshesfahani SH4 ; Mansourian M3
Authors
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Authors Affiliations
  1. 1. Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Neuroscience Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Biostatistics and Epidemiology, Health School, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biology, University of Isfahan, Isfahan, Iran

Source: NeuroImmunoModulation Published:2015


Abstract

Background: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. Vitamin D has been related to the prevention of MS and to modulating its course. Recent studies have shown the safety of high-dose Vitamin D in MS. Objective: This study compared the effects of high-dose Vitamin D on interleukin 10 (IL-10) levels in MS patients in a double-blind, randomized clinical trial. Methods: Ninety-four patients with relapsing remitting MS (RRMS) were randomized into a treatment and a placebo group. Both groups received conventional MS treatment. The intervention group received 50,000 IU of Vitamin D every 5 days for 3 months. IL-10 was measured at baseline and after 3 months. Results: Serum levels of IL-10 were (median ± IQR): 12.58 ± 11.97 and 10.97 ± 9.97 pg/ml in the intervention and placebo groups, respectively, at baseline (p = 0.161); after 3 months, these levels were 13.76 ± 18.95 and 11.31 ± 19.63 pg/ml, respectively (p = 0.158). The IL-10 level increased significantly after receiving high-dose Vitamin D for 3 months (β = 0.737, p = 0.015 and R2 = 0.91). Conclusion: IL-10 levels increased significantly in RRMS patients after taking high-dose Vitamin D3 for 3 months. High-dose Vitamin D might be useful in promoting an anti-inflammatory state in RRMS patients. © 2015 S. Karger AG, Basel.
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