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Associations Between Dietary Intake of B-Vitamins and Psychological Disorders Among Iranian Women: A Cross-Sectional Study Publisher Pubmed



Mozaffari H1 ; Darooghegi Mofrad M1 ; Surkan PJ2 ; Askari M1 ; Azadbakht L1, 3, 4
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, PO Box 1416643931, Tehran, Iran
  2. 2. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States
  3. 3. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Science, Isfahan, Iran

Source: Public Health Nutrition Published:2021


Abstract

Objective: B-vitamins affect brain function through multiple pathways. Given limited evidence on the relationship between dietary intake of these vitamins and psychological disorders, we examined dietary intake of vitamin B6-9-12 in relation to psychological disorders among Iranian women. Design: Cross-sectional study. Dietary intake was assessed using a valid and reliable FFQ. To assess psychological disorders, we used a version of the Depression Anxiety Stress Scale-21 validated in Iran. Setting: Ten public health centres in southern Tehran, Iran. Participants: A total of 447 female participants aged 20-50 years. Results: The median values of vitamin B6 (pyridoxine), B9 (folate) and B12 (cobalamin) were 1·30 mg/d, 313·89 g/d and 3·99 g/d, respectively. After adjustment for potential confounders, dietary vitamin B6 intake was associated with lower odds of depression (OR: 0·54; 95 % CI: 0·31, 0·95; P trend: 0·03). However, there was a positive association between dietary vitamin B12 intake with the odds of depression (OR: 2·05; 95 % CI: 1·17, 3·60; P trend: 0·01) and psychological distress (OR: 2·00; 95 % CI: 1·17, 3·41; P trend: 0·01). No association was found between vitamin B9 with any psychological disorders. Conclusions: Women with higher dietary intakes of vitamin B6 had lower likelihood of depression. However, women with higher dietary intake of vitamin B12 had higher odds of depression and psychological distress. Future prospective studies in different populations are needed to clarify whether B-vitamin deficiency is a cause or consequence of psychological disorders. © 2021 Cambridge University Press. All rights reserved.
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