Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Higher Vitamin B6intake Is Associated With Lower Depression and Anxiety Risk in Women But Not in Men: A Large Cross-Sectional Study Publisher Pubmed



Kafeshani M1 ; Feizi A2, 5, 7 ; Esmaillzadeh A3 ; Keshteli AH4 ; Afshar H5 ; Roohafza H6 ; Adibi P7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Psychosomatic Research Center, Integrative Functional Gastroenterology Research Center, Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Medicine, Univ. of Alberta, Edmonton, Canada, Isfahan Univ. of Med. Sci., Edmonton, Canada
  5. 5. Psychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, Iran
  6. 6. Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal for Vitamin and Nutrition Research Published:2020


Abstract

Objective: The prevalence of depression and anxiety is increasing worldwide. Diet as a modifiable factor for mental health has received great attention. The aim of the present study was to evaluate the association of Vitamin B6 intake with depression and anxiety. Methods: This cross-sectional study was performed among 3362 adults in 2011. Anxiety and depression were evaluated using an Iranian validated version of the Hospital Anxiety and Depression Scale (HADS) questionnaire. Dietary intakes were evaluated by a validated 106 item self-administered Willett-format dish-based semi quantitative food-frequency questionnaire (DFQ). Results: The mean intake of Vitamin B6 (mg/day) was significantly lower in anxious (1.93 ± 0.74 vs. 2.0 ± 0.74; P = 0.02) and depressed (1.86 ± 0.72 vs. 1.99 ± 0.74; P = 0.001) people than healthy participants. The lower level of Vitamin B6 intake (tertile 1), after adjustment for the impacts of various confounding variables, in total population and women was associated with the higher odds of depression (OR = 1.41; 95% CI: 1.19, 2.31; P < 0.001. OR = 1.33; 95% CI: 1.08, 2. 21; P = 0.02, respectively). Also, the lower level of Vitamin B6 intake (tertile 1) in total population and women was associated with the higher odds of anxiety (OR = 2.30; 95% CI: 1.31, 4.04; P < 0. 001, OR = 2.30; 95% CI: 1.19, 4.46; P = 0.04). Conclusion: The association of lower intakes Vitamin B6 intake with increased risk of depression and anxiety was clearly supported by current study. A reasonable approach to tackle these disorders could be the improvement of nutritional status, accordingly large randomized controlled trials are suggested for providing more evidence. ©2019 Hogrefe.
Related Docs
View other Related Docs
1. Associations Between Dietary Intake of B-Vitamins and Psychological Disorders Among Iranian Women: A Cross-Sectional Study, Public Health Nutrition (2021)
2. The Association of Whole and Refined Grains Consumption With Psychological Disorders Among Iranian Adults, European Journal of Nutrition (2019)
3. Dietary Methyl Donor Micronutrients Intake in Relation to Psychological Disorders in Adults, British Journal of Nutrition (2022)
4. The Association Between Dietary Intake of Magnesium and Psychiatric Disorders Among Iranian Adults: A Cross-Sectional Study, British Journal of Nutrition (2018)
5. Adherence to the Mind Diet and Prevalence of Psychological Disorders in Adults, Journal of Affective Disorders (2019)
6. Dietary Total Antioxidant Capacity in Relation to Depression and Anxiety in Iranian Adults, Nutrition (2019)
7. Can Vitamin B6 Help to Prevent Postpartum Depression? a Randomized Controlled Trial, International Journal of Preventive Medicine (2021)
8. Do Patterns of Nutrient Intake Predict Self-Reported Anxiety, Depression and Psychological Distress in Adults? Sepahan Study, Clinical Nutrition (2019)
Experts (# of related papers)
View all Related Experts
Peyman Adibi (62)
Hamid Afshar Zanjani (48)
Other Related Docs
9. Dietary Riboflavin Intake in Relation to Psychological Disorders in Iranian Adults: An Observational Study, Scientific Reports (2023)
10. Consumption of Fruit and Vegetables in Relation With Psychological Disorders in Iranian Adults, European Journal of Nutrition (2018)
11. Empirically Derived Dietary Patterns in Relation to Psychological Disorders, Public Health Nutrition (2016)
12. Empirically Derived Food-Based Dietary Inflammatory Index Is Associated With Increased Risk of Psychological Disorders in Women, Nutritional Neuroscience (2021)
13. Adherence to Mediterranean Dietary Pattern Is Inversely Associated With Depression, Anxiety and Psychological Distress, Nutritional Neuroscience (2021)
14. Consumption of Dietary Fiber in Relation to Psychological Disorders in Adults, Frontiers in Psychiatry (2021)
15. Association Between Dietary Inflammatory Index and Psychological Profile in Adults, Clinical Nutrition (2019)
16. Legume and Nut Consumption in Relation to Depression, Anxiety and Psychological Distress in Iranian Adults, European Journal of Nutrition (2020)
17. Egg Consumption and Prevalence of Psychological Disorders in Adults, European Journal of Nutrition (2019)
18. Combined Healthy Lifestyle Is Inversely Associated With Psychological Disorders Among Adults, PLoS ONE (2016)
19. Adherence to the Dash Diet in Relation to Psychological Profile of Iranian Adults, European Journal of Nutrition (2017)
20. Dietary Acid Load in Relation to Depression and Anxiety in Adults, Journal of Human Nutrition and Dietetics (2020)
21. Psychological Disorders and Dietary Patterns by Reduced-Rank Regression, European Journal of Clinical Nutrition (2019)
22. Association of Serum Vitamin D and Total Antioxidant Capacity Levels With Stress and Anxiety in Young Female Students, Iranian Journal of Psychiatry and Behavioral Sciences (2017)
23. Coffee and Caffeine Intake in Relation to Symptoms of Psychological Disorders Among Adults, Public Health Nutrition (2022)
24. Glycemic Index, Glycemic Load, and Common Psychological Disorders, American Journal of Clinical Nutrition (2016)
25. Association Between the Dietary Inflammatory Index and Common Mental Health Disorders Profile Scores, Clinical Nutrition (2019)
26. The Relationship Between Linoleic Acid Intake and Psychological Disorders in Adults, Frontiers in Nutrition (2022)
27. The Association of the Prime Diet Quality Score (Pdqs) With Depression and Anxiety Symptoms: The Isfahan Functional Disorders (Isfun) Cohort Study, Nutritional Neuroscience (2025)
28. Association of Dietary Phytochemical Index and Mental Health in Women: A Cross-Sectional Study, British Journal of Nutrition (2019)
29. The Prevalence of Depression and Anxiety and Their Lifestyle Determinants in a Large Sample of Iranian Adults: Results From a Population Based Cross-Sectional Study; [Prevalencija Depresije I Anksioznosti I Njihovih Determinanti Zivota U Velikom Uzorku Iranaca: Rezultati Studije Preseka], Serbian Journal of Experimental and Clinical Research (2020)
30. Comparing the Effectiveness of Vitamin D Plus Iron Vs Vitamin D on Depression Scores in Anemic Females: Randomized Triple-Masked Trial, Medical Journal of the Islamic Republic of Iran (2019)
31. Dietary Intake of Branched-Chain Amino Acids in Relation to Depression, Anxiety and Psychological Distress, Nutrition Journal (2021)
32. Red and White Meat Intake in Relation to Mental Disorders in Iranian Adults, Frontiers in Nutrition (2021)
33. The Association of Plant-Based Dietary Patterns and Psychological Disorders Among Iranian Adults, Journal of Affective Disorders (2022)
34. The Effect of Vitamin B6 on Dexamethasone-Induced Depression in Mice Model of Despair, Nutritional Neuroscience (2019)
35. Breakfast Skipping Alone and in Interaction With Inflammatory Based Quality of Diet Increases the Risk of Higher Scores of Psychological Problems Profile in a Large Sample of Iranian Adults, Journal of Nutritional Science (2021)
36. Adherence to Low Carbohydrate Diet and Prevalence of Psychological Disorders in Adults, Nutrition Journal (2019)
37. Effect of Concomitant Administration of Three Different Antidepressants With Vitamin B6 on Depression and Obsessive Compulsive Disorder in Mice Models, Research in Pharmaceutical Sciences (2017)
38. Vitamin B6 Antidepressant Effects Are Comparable to Common Antidepressant Drugs in Bacillus-Calmette-Guerin Induced Depression Model in Mice, Iranian Journal of Psychiatry (2022)
39. Monosodium Glutamate Influences Depressive Behavior of Two Age Groups of Mice in Forced Swimming Test: Vitamin B6 Could Remedy the Situation, Personalized Medicine in Psychiatry (2019)
40. Breakfast Consumption in Relation to Lowered Risk of Psychological Disorders Among Iranian Adults, Public Health (2019)
41. Substituting Whole Grains for Refined Grains and Risk of Developing Psychological Disorders in Iranian Adults: Yahs and Tamyz Studies, Current Psychology (2023)
42. The Relationship Between the World Index for Sustainability and Health (Wish) Score and Mental Health in Women: A Cross-Sectional Study, British Journal of Nutrition (2024)
43. Psychological Status and Quality of Life in Relation to the Metabolic Syndrome: Isfahan Cohort Study, International Journal of Endocrinology (2012)
44. Association Between Dietary Insulin Index and Load and Psychological Disorders, British Journal of Nutrition (2020)
45. Adherence to Alternative Healthy Eating Index in Relation to Depression and Anxiety in Iranian Adults, British Journal of Nutrition (2016)
46. Effect of Vitamin D Supplement on Mood Status and Inflammation in Vitamin D Deficient Type 2 Diabetic Women With Anxiety: A Randomized Clinical Trial, International Journal of Preventive Medicine (2019)
47. The Association Between B Vitamins and the Risk of Covid-19, British Journal of Nutrition (2023)
48. How Five-Factor Personality Traits Affect Psychological Distress and Depression? Results From a Large Population-Based Study, Psychological Studies (2019)
49. The Association of Dietary Macronutrient Quality Indices With Depression and Anxiety Symptoms and Quality of Life in Iranian Adults: The Lipokap Study, Journal of Affective Disorders (2022)
50. The Association of Ultra-Processed Food Consumption With Adult Mental Health Disorders: A Systematic Review and Dose-Response Meta-Analysis of 260,385 Participants, Nutritional Neuroscience (2023)