Circular Rnas: Novel Actors of Wnt Signaling Pathway in Lung Cancer Progression

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Share this content! On (X network) By

Circular Rnas: Novel Actors of Wnt Signaling Pathway in Lung Cancer Progression Publisher

Alimohammadi M¹ ; Gholinezhad Y² ; Mousavi V³ ; Kahkesh S⁴ ; Rezaee M² ; Yaghoobi A² ; Mafi A^{5, 6} ; Araghi M⁷

Show Affiliations

1. Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
4. Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
5. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
6. Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
7. Department of Pathology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Source: EXCLI Journal Published:2023

Abstract

Circular RNAs (CircRNAs) are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. CircRNA dysregulation has been shown to disrupt the interaction of the Wnt/β-catenin pathway, which regulates several biological processes involved in tumorigenesis, thereby contributing to the development and progression of cancer. Interactions of tumor-derived circRNAs with the Wnt/β-catenin signaling pathway provide both clinical diagnostic biomarkers and promising therapeutic targets. In this review, we outlined current evidence on the roles of circRNAs associated with the Wnt/β-catenin pathway in regulating lung cancer formation and development. We believe that our findings will assist in the advancement or establishment of circRNA-based lung cancer therapeutic approaches. © 2023, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.

Related Docs

View other Related Docs

1. A Spotlight on the Interplay Between Wnt/Β-Catenin Signaling and Circular Rnas in Hepatocellular Carcinoma Progression, Frontiers in Oncology (2023)

2. The Importance of the Circrna/Wnt Axis in Gliomas: Biological Functions and Clinical Opportunities, Pathology Research and Practice (2024)

3. Circular Rnas and Cervical Cancer: Friends or Foes? a Landscape on Circrna-Mediated Regulation of Key Signaling Pathways Involved in the Onset and Progression of Hpv-Related Cervical Neoplasms, Cell Communication and Signaling (2024)

4. Circular Rnas-Mediated Angiogenesis in Human Cancers, Clinical and Translational Oncology (2023)

5. Circular Rnas and Glioblastoma Multiforme: Focus on Molecular Mechanisms, Cell Communication and Signaling (2022)

6. Circular Rnas: Epigenetic Regulators in Cancerous and Noncancerous Skin Diseases, Cancer Gene Therapy (2020)

7. The Regulatory Role of Circular Rnas As Mirna Sponges in Cervical Cancer, Current Signal Transduction Therapy (2023)

8. Circular Rnas: New Players in Thyroid Cancer, Pathology Research and Practice (2020)

Experts (# of related papers)

View all Related Experts

Maryam Derakhshan (4)

Parvaneh Nikpour (3)

Other Related Docs

9. Melatonin Targeting Non-Coding Rnas in Cancer: Focus on Mechanisms and Potential Therapeutic Targets, European Journal of Pharmacology (2023)

10. The Potential Role of Circular Rnas -Regulated Pi3k Signaling in Non-Small Cell Lung Cancer: Molecular Insights and Clinical Perspective, Pathology Research and Practice (2024)

11. The Emerging Role of Circular Rnas in Cisplatin Resistance in Ovarian Cancer: From Molecular Mechanism to Future Potential, Non-coding RNA Research (2024)

12. Non-Coding Rnas and Glioblastoma: Insight Into Their Roles in Metastasis, Molecular Therapy Oncolytics (2022)

13. Mechanistic Insights Into Circrna-Mediated Regulation of Pi3k Signaling Pathway in Glioma Progression, Pathology Research and Practice (2024)

14. Circular Rnas: Emerging Modulators in the Pathophysiology of Polycystic Ovary Syndrome and Their Clinical Implications, Current Molecular Medicine (2024)

15. Circular Rnas: Pivotal Role in the Leukemogenesis and Novel Indicators for the Diagnosis and Prognosis of Acute Myeloid Leukemia, Frontiers in Oncology (2023)

16. Down-Regulation of Circular Rna Itch and Circhipk3 in Gastric Cancer Tissues, Turkish Journal of Medical Sciences (2019)

17. Novel Insights Into the Role of Circular Rnas in Parkinson Disease: An Emerging Renaissance in the Management of Neurodegenerative Diseases, Journal of Neuroscience Research (2022)

18. Non-Coding Rnas in Leukemia Drug Resistance: New Perspectives on Molecular Mechanisms and Signaling Pathways, Annals of Hematology (2024)

19. Recent Insights Into the Roles of Circular Rnas in Human Brain Development and Neurologic Diseases, International Journal of Biological Macromolecules (2023)

20. Circular Rnas in Alzheimer’S Disease: A New Perspective of Diagnostic and Therapeutic Targets, CNS and Neurological Disorders - Drug Targets (2023)

21. Circular Rnas: New Genetic Tools in Melanoma, Biomarkers in Medicine (2020)

22. A Comprehensive Insight Into the Correlation Between Ncrnas and the Wnt/Β-Catenin Signalling Pathway in Gastric Cancer Pathogenesis, Cell Communication and Signaling (2023)

23. Micrornas Regulating Wnt Signaling Pathway in Colorectal Cancer: Biological Implications and Clinical Potentials, Functional and Integrative Genomics (2022)

24. The Landscape of Exosomal Non-Coding Rnas in Breast Cancer Drug Resistance, Focusing on Underlying Molecular Mechanisms, Frontiers in Pharmacology (2023)

25. Pi3k/Akt/Mtor Signaling Pathway Modulation by Circular Rnas in Breast Cancer Progression, Pathology Research and Practice (2023)

26. Circular Rnas; Powerful Microrna Sponges to Overcome Diabetic Nephropathy, Pathology Research and Practice (2021)

27. Comprehensive Competitive Endogenous Rna Network Analysis Reveals Ezh2-Related Axes and Prognostic Biomarkers in Hepatocellular Carcinoma, Iranian Journal of Basic Medical Sciences (2022)

28. Micrornas, Long Non-Coding Rnas, and Circular Rnas and Gynecological Cancers: Focus on Metastasis, Frontiers in Oncology (2023)

29. Exploring Conserved Mrna-Mirna Interactions in Colon and Lung Cancers, Gastroenterology and Hepatology from Bed to Bench (2017)

30. Mechanisms of Apoptosis-Related Non-Coding Rnas in Ovarian Cancer: A Narrative Review, Apoptosis (2025)

31. Multiple Function of Lncrna Malat1 in Cancer Occurrence and Progression, Chemical Biology and Drug Design (2023)

32. Lncrna Flvcr1-As1 Sponges Mir-381-3P and Promotes Wnt Signaling Pathway Resulting in Colorectal Cancer Progression, Egyptian Journal of Medical Human Genetics (2025)

33. The Function and Mechanism of Circrnas in 5-Fluorouracil Resistance in Tumors: Biological Mechanisms and Future Potential, Pathology Research and Practice (2024)

34. Analysis of a Four-Component Competing Endogenous Rna Network Reveals Potential Biomarkers in Gastric Cancer: An Integrated Systems Biology and Experimental Investigation, Advanced Biomedical Research (2023)

35. Micrornas and Target Molecules in Bladder Cancer, Medical Oncology (2020)

36. The Landscape of Circrnas in Gliomas Temozolomide Resistance: Insights Into Molecular Pathways, Non-coding RNA Research (2024)

37. Mir-1236: Key Controller of Tumor Development and Progression: Focus on the Biological Functions and Molecular Mechanisms, Pathology Research and Practice (2023)

38. Competing Endogenous Rnas Regulatory Crosstalk Networks: The Messages From the Rna World to Signaling Pathways Directing Cancer Stem Cell Development, Heliyon (2024)

39. Interplays Between Non-Coding Rnas and Chemokines in Digestive System Cancers, Biomedicine and Pharmacotherapy (2022)

40. Circular Rnas: A Small Piece in the Heart Failure Puzzle, Functional and Integrative Genomics (2024)

41. Tgf-Β and Wnt Signaling Pathways in Cardiac Fibrosis: Non-Coding Rnas Come Into Focus, Cell Communication and Signaling (2020)

Style	Citing Format
MLA	Alimohammadi M, et al.. "Circular Rnas: Novel Actors of Wnt Signaling Pathway in Lung Cancer Progression." EXCLI Journal, vol. 22, no. , 2023, pp. 645-669.
APA	Alimohammadi M, Gholinezhad Y, Mousavi V, Kahkesh S, Rezaee M, Yaghoobi A, Mafi A, Araghi M (2023). Circular Rnas: Novel Actors of Wnt Signaling Pathway in Lung Cancer Progression. EXCLI Journal, 22(), 645-669.
Chicago	Alimohammadi M, Gholinezhad Y, Mousavi V, Kahkesh S, Rezaee M, Yaghoobi A, Mafi A, Araghi M. "Circular Rnas: Novel Actors of Wnt Signaling Pathway in Lung Cancer Progression." EXCLI Journal 22, no. (2023): 645-669.
Harvard	Alimohammadi M et al. (2023) 'Circular Rnas: Novel Actors of Wnt Signaling Pathway in Lung Cancer Progression', EXCLI Journal, 22(), pp. 645-669.
Vancouver	Alimohammadi M, Gholinezhad Y, Mousavi V, Kahkesh S, Rezaee M, Yaghoobi A, et al.. Circular Rnas: Novel Actors of Wnt Signaling Pathway in Lung Cancer Progression. EXCLI Journal. 2023;22():645-669.
BibTex	@article{ author = {Alimohammadi M and Gholinezhad Y and Mousavi V and Kahkesh S and Rezaee M and Yaghoobi A and Mafi A and Araghi M}, title = {Circular Rnas: Novel Actors of Wnt Signaling Pathway in Lung Cancer Progression}, journal = {EXCLI Journal}, volume = {22}, number = {}, pages = {645-669}, year = {2023} }
RIS	TY - JOUR AU - Alimohammadi M AU - Gholinezhad Y AU - Mousavi V AU - Kahkesh S AU - Rezaee M AU - Yaghoobi A AU - Mafi A AU - Araghi M TI - Circular Rnas: Novel Actors of Wnt Signaling Pathway in Lung Cancer Progression JO - EXCLI Journal VL - 22 IS - SP - 645 EP - 669 PY - 2023 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract