Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effects and Mechanisms of Fisetin Against Ischemia-Reperfusion Injuries: A Systematic Review Publisher Pubmed



Adeli OA1, 2 ; Heidarisoureshjani S3 ; Rostamian S4 ; Azadegandehkordi Z5 ; Khaghani A6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pathology, Lorestan University of Medical Sciences, Khorramabad, Iran
  2. 2. Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  3. 3. Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
  4. 4. Department of Medicine, Harvard Medical School, Boston, MA, United States
  5. 5. Oriented Nursing Midwifery Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
  6. 6. Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Current Pharmaceutical Biotechnology Published:2024


Abstract

Background: Ischemia-reperfusion injury (IRI) is a well-known ailment that can disturb organ function. Objectives: This systematic review study investigated fisetin's effects and possible mechanisms in attenuating myocardial, cerebral, renal, and hepatic IRIs. Methods: This systematic review included studies earlier than Sep 2023 by following the PRISMA statement 2020. After determining inclusion and exclusion criteria and related keywords, bibliographic databases, such as Cochrane Library, PubMed, Web of Science, Embase, and Scopus databases, were used to search the relevant studies. Studies were imported in End-Note X8, and the primary information was recorded in Excel. Results: Fisetin reduced reactive oxygen species (ROS) generation and upregulated antioxidant enzymes, such as superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), and glutathione peroxidase (GPx), in ischemic tissues. Moreover, fisetin can attenuate oxidative stress by activating phosphoinositide-3-kinase–protein kinase B/Akt (PI3K/Akt) and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways. Fisetin has been indicated to prevent the activation of several pro-inflammatory signaling pathways, including NF-κB (Nuclear factor kappa-light-chain-enhancer of activated B cells) and MAPKs (Mitogen-activated protein kinases). It also inhibits the production of pro-inflammatory cytokines and enzymes like tumor necrosis factor-a (TNF-α), inducible-NO synthase (iNOS), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), interleukin-1β (IL-1β), IL-1, and IL-6. Fisetin attenuates IRI by improving mito-chondrial function, anti-apoptotic effects, promoting autophagy, and preserving tissues from histological changes induced by IRIs. Conclusion: Fisetin, by antioxidant, anti-inflammatory, mitochondrial protection, promoting autophagy, and anti-apoptotic properties, can reduce cell injury due to myocardial, cerebral renal, and hepatic IRIs without any significant side effects. © 2024 Bentham Science Publishers.
Related Docs
View other Related Docs
1. Neuroprotective Effects of Flavonoids, Phytonutrients and Neurological Disorders: Therapeutic and Toxicological Aspects (2023)
2. Cardiopulmonary Protective Effects of Alprostadil and Hydrocortisone Against Distant Organ Reperfusion After Hind Limb Ischemia in Rat Model, Italian Journal of Vascular and Endovascular Surgery (2015)
3. Protective Effects of Pioglitazone in Renal Ischemia–Reperfusion Injury (Riri): Focus on Oxidative Stress and Inflammation, Clinical and Experimental Nephrology (2024)
4. L-Carnitine and Potential Protective Effects Against Ischemia-Reperfusion Injury in Noncardiac Organs: From Experimental Data to Potential Clinical Applications, Journal of Dietary Supplements (2018)
5. How Effective Are Alprostadil and Hydrocortisone on Reperfusion Injury in Kidney After Distant Organ Ischemia?, Journal of Research in Medical Sciences (2013)
6. The Protective Roles of Zinc and Estradiol in Renal Ischemia/Reperfusion Injury in Ovariectomized Rats, Journal of Nephropathology (2018)
7. Pretreatment Effect of D-Limonene on Oxidative Stress Induced by Renal Ischemia-Reperfusion Injury in Rats, Journal of Babol University of Medical Sciences (2022)
8. Protective Role of Recombinant Human Erythropoietin in Kidney and Lung Injury Following Renal Bilateral Ischemia-Reperfusion in Rat Model, International Journal of Preventive Medicine (2013)
Experts (# of related papers)
View all Related Experts
Mehdi Nematbakhsh (5)
Leila Safaeian (5)
Other Related Docs
9. Reactive Oxygen Metabolites and Anti-Oxidative Defenses in Aspirin-Induced Gastric Damage in Rats: Gastroprotection by Vitamin E, Pathophysiology (2006)
10. The Effect of Astaxanthin Supplementation on Inflammatory Markers, Oxidative Stress Indices, Lipid Profile, Uric Acid Level, Blood Pressure, Endothelial Function, Quality of Life, and Disease Symptoms in Heart Failure Subjects, Trials (2024)
11. Evolocumab, a Pcsk9 Inhibitor, Protects Human Endothelial Cells Against H2o2-Induced Oxidative Stress, Archives of Physiology and Biochemistry (2022)
12. Tramadol Alleviates Myocardial Injury Induced by Acute Hindlimb Ischemia Reperfusion in Rats; [Tramadol Atenua Lesoes Miocardicas Induzidas Pela Reperfusao Pos- Isquemica Aguda De Membros Posteriores Em Ratos], Arquivos Brasileiros de Cardiologia (2015)
13. Protective Potential of Naringenin and Its Nanoformulations in Redox Mechanisms of Injury and Disease, Heliyon (2023)
14. Protective Effect of Quercetin on Alteration of Antioxidant Genes Expression and Histological Changes in the Dental Pulp of the Streptozotocin-Diabetic Rats, Archives of Oral Biology (2021)
15. Preconditioning With Diosgenin and Treadmill Exercise Preserves the Cardiac Toxicity of Isoproterenol in Rats, Journal of Physiology and Biochemistry (2013)
16. Sodium Hydrogen Sulfide May Not Protect the Kidney Against Ischemia/Reperfusion Damage in Male and Female Rats, Research in Pharmaceutical Sciences (2023)
17. Has Vitamin E Any Shreds of Evidence in Cisplatin-Induced Toxicity, Journal of Biochemical and Molecular Toxicology (2019)
18. Coenzyme Q10 Supplementation and Oxidative Stress Parameters: A Systematic Review and Meta-Analysis of Clinical Trials, European Journal of Clinical Pharmacology (2020)
19. Effects of Light-Emitting Diode (Led) Therapy on Skeletal Muscle Ischemia Reperfusion in Rats, Lasers in Medical Science (2015)
20. An Engineered Non-Erythropoietic Erythropoietin-Derived Peptide, Ara290, Attenuates Doxorubicin Induced Genotoxicity and Oxidative Stress, Toxicology in Vitro (2020)
21. The Effects of L-Carnitine Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Critically Ill Patients With Sepsis: A Randomized, Double-Blind, Controlled Trial, Nutrition Journal (2024)
22. Systematic Review and Meta-Analysis of Oxidative Stress and Antioxidant Markers in Recurrent Aphthous Stomatitis, BMC Oral Health (2023)
23. Protective Effect of Flavonoids Against Red Blood Cell Hemolysis by Free Radicals, Experimental and Clinical Cardiology (2005)
24. Antioxidant and Cytoprotective Effects of L-Serine on Human Endothelial Cells, Research in Pharmaceutical Sciences (2012)
25. Preventive Effect of Exercise on Lipid Peroxidation and Histopathological Changes in Isoproterenol-Induced Myocardial Infarction in Male Rats, Pharmaceutical Sciences (2010)
26. Nigella Sativa in Controlling Type 2 Diabetes, Cardiovascular, and Rheumatoid Arthritis Diseases: Molecular Aspects, Journal of Research in Medical Sciences (2021)
27. Antioxidant Effects of Astaxanthin and Metformin Combined Therapy in Type 2 Diabetes Mellitus Patients: A Randomized Double-Blind Controlled Clinical Trial, Research in Pharmaceutical Sciences (2022)
28. Cardioprotective Potential of Protocatechuic Acid Against Doxorubicin-Induced Cardiotoxicity in Rats, Research in Pharmaceutical Sciences (2025)
29. Prediction of Short-Term Clinical Outcome of Percutaneous Coronary Intervention in Patients With Acute Coronary Syndrome Through Myeloperoxidase Levels, ARYA Atherosclerosis (2014)
30. Carotenoids As Potential Antioxidant Agents in Stroke Prevention: A Systematic Review, International Journal of Preventive Medicine (2017)
31. Citral Protects Human Endothelial Cells Against Hydrogen Peroxide-Induced Oxidative Stress; [Sitral, Insan Endotel Hucrelerini Hidrojen Peroksitin Neden Oldugu Oksidatif Strese Karsi Korur], Turkish Journal of Pharmaceutical Sciences (2020)
32. Impact of Allopurinol Pretreatment on Coronary Blood Flow and Revascularization Outcomes After Percutaneous Coronary Intervention in Acute Stemi Patients: A Randomized Double Blind Clinical Trial, ARYA Atherosclerosis (2023)
33. The Effect of N-Acetylcysteine in Prime Solution on Reducing Damage to the Myocardium in Open Heart Surgery, Journal of Isfahan Medical School (2024)
34. Rosemary and Its Protective Potencies Against Covid-19 and Other Cytokine Storm Associated Infections: A Molecular Review, Mediterranean Journal of Nutrition and Metabolism (2021)
35. Flavonoids Target Different Molecules of Autophagic and Metastatic Pathways in Cancer Cells, Cancer Cell International (2023)
36. Possible Effects of Melatonin on Reperfusion Injury Following Coronary Artery Bypass Graft Surgery, ARYA Atherosclerosis (2022)
37. Oxidative Stress and Hypertension: Possibility of Hypertension Therapy With Antioxidants, Journal of Research in Medical Sciences (2014)
38. Decreased Na+/K+-Atpase Activity and Altered Susceptibility to Peroxidation and Lipid Composition in the Erythrocytes of Metabolic Syndrome Patients With Coronary Artery Disease, Annals of Nutrition and Metabolism (2019)
39. Effects of Silymarin on the Proliferation and Glutathione Levels of Peripheral Blood Mononuclear Cells From Β-Thalassemia Major Patients, International Immunopharmacology (2006)
40. Trimetazidine As a Modifier of Chemotherapy-Induced Cardiovascular Redox-Homeostasis Disturbances, Kardiologija v Belarusi (2022)
41. Sulfaphenazole Treatment Restores Endothelium-Dependent Vasodilation in Diabetic Mice, Vascular Pharmacology (2008)
42. Antioxidant Effects of Methanol Extract of Dracocephalum Kotschyi in Acetic Acid Induced Rat Colitis Model, Journal of Advances in Medical and Biomedical Research (2022)
43. Hypoxia-Preconditioned Wj-Msc Spheroid-Derived Exosomes Delivering Mir-210 for Renal Cell Restoration in Hypoxia-Reoxygenation Injury, Stem Cell Research and Therapy (2024)
44. Astaxanthin Prevents Nephrotoxicity Through Nrf2/Ho-1 Pathway, Canadian Journal of Physiology and Pharmacology (2024)
45. The Effects of L-Carnitine Supplementation on Inflammatory Factors, Oxidative Stress, and Clinical Outcomes in Patients With Sepsis Admitted to the Intensive Care Unit (Icu): Study Protocol for a Double Blind, Randomized, Placebo-Controlled Clinical Trial, Trials (2022)
46. Selenium Supplementation and Oxidative Stress: A Review, PharmaNutrition (2021)
47. Pathological Mechanisms Induced by Trpm2 Ion Channels Activation in Renal Ischemia-Reperfusion Injury, Molecular Biology Reports (2022)
48. Antihypertensive and Antioxidant Effects of Protocatechuic Acid in Deoxycorticosterone Acetate-Salt Hypertensive Rats, Biomedicine and Pharmacotherapy (2018)
49. Protective Effects of Protocatechuic Acid Against Doxorubicin- and Arsenic Trioxide-Induced Toxicity in Cardiomyocytes, Research in Pharmaceutical Sciences (2023)
50. Reviewing Blood Serum Uric Acid in Patients With Stroke, Journal of Isfahan Medical School (2011)