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Neuroprotective Effects of Flavonoids Publisher



Taghizadieh M1 ; Modiri N2 ; Salmaninejad A3 ; Khayami R4 ; Taheri F5 ; Moghoofei M6 ; Khatami A7 ; Azhdari S8 ; Bayat M9, 10 ; Samadikhouzani A11 ; Sadri Nahand J10
Authors
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Authors Affiliations
  1. 1. Department of Pathology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Student Research Committee, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, East Azerbaijan, Tabriz, Iran
  4. 4. Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Razavi Khorasan, Mashhad, Iran
  5. 5. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  7. 7. Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Anatomy and Embryology, School of Medicine, Bam University of Medical Sciences, Bam, Iran
  9. 9. Department of Plant, Cell and Molecular Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
  10. 10. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  11. 11. Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Chaharmahal and Bakhtiari, Shahrekord, Iran

Source: Phytonutrients and Neurological Disorders: Therapeutic and Toxicological Aspects Published:2023


Abstract

Flavonoids have multiple neuroprotective functions inside the brain. They are including potential neuroprotection against neurotoxins-induced damages, neuroinflammation supersession, and the potential to improve learning, cognitive functions, and memory. These functions seem to be due to two underlying processes. First, interacting lipid kinase signaling pathway with critical protein within the brain. These interactions resulted in apoptosis inhibition initiated by neurotoxin species. They promote synaptic plasticity as well as neuronal survival. Second, they mediated favorable impacts on the vasculature system that alters cerebrovascular blood flow—these changes lead to neurogenesis, neuronal morphology changes, and angiogenesis. Thus, flavonoid-rich foods consumption in life span potentially restricted neurodegeneration and reverse or prevent senescent changes in cognitive function. Great enthusiasm for drug development to enhance brain activity revealed that flavonoids might provide an essential precursor in brain injury medications. © 2023 Elsevier Inc. All rights reserved.
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