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The Effects of Supplementation With L-Arginine on Anthropometric Indices and Body Composition in Overweight or Obese Subjects: A Systematic Review and Meta-Analysis Publisher



Zeinali Khosroshahi M1 ; Asbaghi O1 ; Moradi S2, 3 ; Rezaei Kelishadi M4 ; Kaviani M5 ; Mardani M6 ; Jalili C7
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
  2. 2. Halal Research Centre of IRI, FDA, Tehran, Iran
  3. 3. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Faculty of Pure & Applied Science, School of Nutrition and Dietetics, Acadia University, Wolfville, NS, Canada
  6. 6. Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  7. 7. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Journal of Functional Foods Published:2020


Abstract

Background: Animal studies have shown that L-Arginine can affect anthropometric and body composition indices favorably, while results of human studies are contradictory. Objective: This is a meta-analysis of human studies in which L-arginine was provided as a dietary supplement to test its effects on anthropometric indices. Design: We searched the Cochrane library, PubMed, Embase and Scopus databases to identify studies in which L-arginine was provided to humans in randomized clinical trials. Results: Of 4784 publications, 12 trials were included for the meta-analysis. Pooled effect sizes indicated that L-arginine significantly reduced body mass index (BMI), waist circumference (WC), and fat mass (FM), and also increased fat-free mass (FFM) compared to the placebo group. However, the effects of L-arginine on body weight (BW) was not significant. Subgroup analysis could not identify factors significantly influencing BW. Conclusion: We found a beneficial effect of L-arginine supplementation on anthropometric indices in overweight and obese subjects. © 2020
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