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Association of Il-6 -176G > C Polymorphism With Susceptibility to Preeclampsia: A Systematic Review and Meta-Analysis Publisher Pubmed



Veisian M1 ; Javaheri A2 ; Amjadi N3 ; Tabatabaei RS2 ; Zanbagh L2, 4 ; Hadadan A2, 3 ; Abbasi H3 ; Salimi E3 ; Dastgheib SA5 ; Neamatzadeh H6, 7
Authors
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Authors Affiliations
  1. 1. Department of Gynecology and Obstetrics, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  3. 3. Department of Gynecology and Obstetrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  7. 7. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: Fetal and Pediatric Pathology Published:2020


Abstract

Background: Many studies have described the influence of -176G > C polymorphism of the IL-6 gene on susceptibility to preeclampsia. However, the results have remained inconclusive and controversial. Therefore, we performed a meta-analysis to more precisely determine the association between the IL-6 -176G > C polymorphism and preeclampsia risk. Methods: Electronic databases including PubMed, Embase, Web of Science, and CNKI were searched up to August 15, 2019. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were used to calculate the association. Results: A total of 12 studies with 1,821 preeclampsia cases and 3,339 controls were selected. Overall, no significant association was found between IL-6 -176G > C polymorphism and preeclampsia risk. In the stratified analyses by ethnicity, there was a significant association in Asians, but not in Caucasians and mixed populations. Conclusions: The results of meta-analysis indicated that IL-6 -176G > C polymorphism was not significantly associated with risk of preeclampsia in overall population. © 2019 Taylor & Francis Group, LLC.
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