Association of Interleukin-10 -1082G > a Polymorphism With Susceptibility to Preeclampsia: A Systematic Review and Meta-Analysis Based on 21 Studies Publisher Pubmed



Veisian M¹ ; Tabatabaei RS² ; Javaheri A² ; Abbasi H³ ; Salimi E³ ; Hadadan A³ ; Zanbagh L² ; Dastgheib SA⁴ ; Neamatzadeh H^{5, 6}
Source: Fetal and Pediatric Pathology Published:2020

Abstract

Background: Previous studies have reported the association between IL-10 -1082 G > A polymorphism and preeclampsia risk, but the results remained controversial. Therefore, this meta-analysis was performed to evaluate the association of IL-10 -1082 G > A polymorphism with preeclampsia risk. Methods: We searched PubMed, ISI Web of Knowledge and CNKI databases to identify eligible studies up to September 05, 2019. Results: A total of 21 case-control studies with 3,510 cases and 5,874 controls were selected. The results revealed that IL-10 -1082 G > A polymorphism was significantly associated with an increased risk of preeclampsia under the recessive model (AA vs. AG + GG: OR = 1.191, 95% CI = 1.018–1.394, P = 0.029). Stratified analyses by ethnicity revealed a significantly increased risk of preeclampsia in Asian and mixed populations, but not in Caucasians. Moreover, there was a significant association among Chinese and Brazilian. Conclusions: Our results showed that IL-10 -1082 G > A polymorphism was significantly associated with an increased risk of preeclampsia. © 2019 Taylor & Francis Group, LLC.