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The Association Between Enteral Nutrition With Survival of Critical Patients With Covid-19 Publisher Pubmed



Gholamalizadeh M1 ; Salimi Z2 ; Mobarakeh KA3 ; Mahmoudi Z4 ; Tajadod S5 ; Mousavi Mele M6 ; Alami F7 ; Bahar B8 ; Doaei S1 ; Khoshdooz S9 ; Rahvar M10 ; Gholami S10 ; Pourtaleb M10
Authors
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Authors Affiliations
  1. 1. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Community Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Nutrition, Science and Research Branch Islamic Azad University, Tehran, Iran
  5. 5. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, International Campus, Tehran, Iran
  6. 6. Department of Nutrition, University of Medical Sciences, Tehran, Iran
  7. 7. Nutrition Sciences and Applied Food Safety Studies, Research Centre for Global Development, School of Sport and Health Sciences, University of Central Lancashire, Preston, United Kingdom
  8. 8. Department of Nutrition, Student Research Committee, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  9. 9. Razi Clinical Research Development Unit, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran
  10. 10. Intensive Care Unit (ICU), Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran

Source: Immunity, Inflammation and Disease Published:2024


Abstract

Background: Coronavirus disease 2019 (COVID-19) results in several complications and mortality in intensive care unit (ICU) patients. Limited studies have investigated the effect of enteral nutrition (EN) on the survival of COVID-19 patients in the ICU. The aim of this study was to investigate the association of EN with biochemical and pathological indices associated with mortality in ICU patients with COVID-19. Methods: This case–control study was conducted on 240 patients with COVID-19 hospitalized in the ICU including 120 eventual nonsurvived as the cases and 120 survived patients as the controls. All of the patients received EN as a high protein high volume or standard formula. Data on general information, anthropometric measurements, and the results of lab tests were collected. Results: The recovered patients received significantly more high protein (60.8% vs. 39.6%, p =.004) and high volume (61.6% vs. 42.3%, p =.005) formula compared to the nonsurvived group. Mortality was inversely associated with high volume (odds ratio [OR]: 0.45 confidence interval [CI]95%, p =.008) and high protein (OR: 0.42 CI95%, p =.003) formula. The results remained significant after adjusting for age and sex. Further adjustment for underlying diseases, smoking, body mass index, and the acute physiology and chronic health evaluation II (APACHE II) score did not change the results. Conclusion: The findings of the study showed that there was a significant inverse association between mortality and high volume and high protein formula in patients with COVID-19. Further investigation is warranted. © 2024 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.
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