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The Association Between Vitamin D Intake With Inflammatory and Biochemical Indices and Mortality in Critically Ill Patients With Covid-19: A Case-Control Study Publisher Pubmed



Gholamalizadeh M1 ; Rabbani F2 ; Ahmadzadeh M3 ; Hajipour A4 ; Musavi H5 ; Mobarakeh KA6 ; Salimi Z7 ; Bahar B8 ; Mahmoodi Z9 ; Gholami S10 ; Mirzaei Dahka S11 ; Doaei S12 ; Akbari ME1
Authors
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Authors Affiliations
  1. 1. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  3. 3. Department of Clinical Nutrition and Dietetics, National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. School of Health, Qazvin University of Medical Sciences, Qazvin, Iran
  5. 5. Tabriz University of Medical Sciences, Rasht, Iran
  6. 6. Department of Community Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  8. 8. Nutrition Sciences and Applied Food Safety Studies, Research Centre for Global Development, School of Sport & Health Sciences, University of Central Lancashire, Preston, United Kingdom
  9. 9. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  10. 10. Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran
  11. 11. School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran
  12. 12. Department of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Immunity, Inflammation and Disease Published:2023


Abstract

Background: The coronavirus disease-2019 (COVID-19) has become a worldwide health issue with widespread hospitalization and dependence on the intensive care unit (ICU). Vitamin D has a key role in modulating immune cells and modulating the inflammatory responses. This study aimed to investigate the association of vitamin D supplementation with inflammatory, biochemical, and mortality indices in critically ill patients with COVID-19. Methods: This case-control study was conducted on critically ill COVID-19 patients hospitalized in the ICU including the survived >30 day patients as the case group and dead patients as the control group. The status of vitamin D supplementation and inflammatory and biochemical indices of the patients were retrieved from the medical records. Logistic regression method was used to assess the association between 30 days survival and vitamin D supplement intake. Results: Compared to the group of COVID-19 patients who died in <30 day, the survived patients had a lower eosinophile level (2.2 ± 0.5 vs. 6 ± 0.0, p <.001) and higher vitamin D supplementation duration (9 ± 4.4 vs. 3.3 ± 1.9 day, p =.001). Vitamin D supplementation had a positive association with survival in COVID-19 patients (OR: 1.98, 95% CI: 1.15−3.40, p <.05). The association remained significant after adjustments fot age, sex, underlying diseases, and smoking. Conclusion: Vitamin D supplementation in critically ill patients with COVID-19 has the potential to increase survivability within the first 30 days of hospitalization. © 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.
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