The Association Between Vitamin D Intake With Inflammatory and Biochemical Indices and Mortality in Critically Ill Patients With Covid-19: A Case-Control Study

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The Association Between Vitamin D Intake With Inflammatory and Biochemical Indices and Mortality in Critically Ill Patients With Covid-19: A Case-Control Study Publisher Pubmed

Gholamalizadeh M¹ ; Rabbani F² ; Ahmadzadeh M³ ; Hajipour A⁴ ; Musavi H⁵ ; Mobarakeh KA⁶ ; Salimi Z⁷ ; Bahar B⁸ ; Mahmoodi Z⁹ ; Gholami S¹⁰ ; Mirzaei Dahka S¹¹ ; Doaei S¹² ; Akbari ME¹

Source: Immunity, Inflammation and Disease Published:2023

Abstract

Background: The coronavirus disease-2019 (COVID-19) has become a worldwide health issue with widespread hospitalization and dependence on the intensive care unit (ICU). Vitamin D has a key role in modulating immune cells and modulating the inflammatory responses. This study aimed to investigate the association of vitamin D supplementation with inflammatory, biochemical, and mortality indices in critically ill patients with COVID-19. Methods: This case-control study was conducted on critically ill COVID-19 patients hospitalized in the ICU including the survived >30 day patients as the case group and dead patients as the control group. The status of vitamin D supplementation and inflammatory and biochemical indices of the patients were retrieved from the medical records. Logistic regression method was used to assess the association between 30 days survival and vitamin D supplement intake. Results: Compared to the group of COVID-19 patients who died in <30 day, the survived patients had a lower eosinophile level (2.2 ± 0.5 vs. 6 ± 0.0, p <.001) and higher vitamin D supplementation duration (9 ± 4.4 vs. 3.3 ± 1.9 day, p =.001). Vitamin D supplementation had a positive association with survival in COVID-19 patients (OR: 1.98, 95% CI: 1.15−3.40, p <.05). The association remained significant after adjustments fot age, sex, underlying diseases, and smoking. Conclusion: Vitamin D supplementation in critically ill patients with COVID-19 has the potential to increase survivability within the first 30 days of hospitalization. © 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.

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Style	Citing Format
MLA	Gholamalizadeh M, et al.. "The Association Between Vitamin D Intake With Inflammatory and Biochemical Indices and Mortality in Critically Ill Patients With Covid-19: A Case-Control Study." Immunity, Inflammation and Disease, vol. 11, no. 4, 2023, pp. -.
APA	Gholamalizadeh M, Rabbani F, Ahmadzadeh M, Hajipour A, Musavi H, Mobarakeh KA, Salimi Z, Bahar B, Mahmoodi Z, Gholami S, Mirzaei Dahka S, Doaei S, Akbari ME (2023). The Association Between Vitamin D Intake With Inflammatory and Biochemical Indices and Mortality in Critically Ill Patients With Covid-19: A Case-Control Study. Immunity, Inflammation and Disease, 11(4), -.
Chicago	Gholamalizadeh M, Rabbani F, Ahmadzadeh M, Hajipour A, Musavi H, Mobarakeh KA, Salimi Z, et al.. "The Association Between Vitamin D Intake With Inflammatory and Biochemical Indices and Mortality in Critically Ill Patients With Covid-19: A Case-Control Study." Immunity, Inflammation and Disease 11, no. 4 (2023): -.
Harvard	Gholamalizadeh M et al. (2023) 'The Association Between Vitamin D Intake With Inflammatory and Biochemical Indices and Mortality in Critically Ill Patients With Covid-19: A Case-Control Study', Immunity, Inflammation and Disease, 11(4), pp. -.
Vancouver	Gholamalizadeh M, Rabbani F, Ahmadzadeh M, Hajipour A, Musavi H, Mobarakeh KA, et al.. The Association Between Vitamin D Intake With Inflammatory and Biochemical Indices and Mortality in Critically Ill Patients With Covid-19: A Case-Control Study. Immunity, Inflammation and Disease. 2023;11(4):-.
BibTex	@article{ author = {Gholamalizadeh M and Rabbani F and Ahmadzadeh M and Hajipour A and Musavi H and Mobarakeh KA and Salimi Z and Bahar B and Mahmoodi Z and Gholami S and Mirzaei Dahka S and Doaei S and Akbari ME}, title = {The Association Between Vitamin D Intake With Inflammatory and Biochemical Indices and Mortality in Critically Ill Patients With Covid-19: A Case-Control Study}, journal = {Immunity, Inflammation and Disease}, volume = {11}, number = {4}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Gholamalizadeh M AU - Rabbani F AU - Ahmadzadeh M AU - Hajipour A AU - Musavi H AU - Mobarakeh KA AU - Salimi Z AU - Bahar B AU - Mahmoodi Z AU - Gholami S AU - Mirzaei Dahka S AU - Doaei S AU - Akbari ME TI - The Association Between Vitamin D Intake With Inflammatory and Biochemical Indices and Mortality in Critically Ill Patients With Covid-19: A Case-Control Study JO - Immunity, Inflammation and Disease VL - 11 IS - 4 SP - EP - PY - 2023 ER -