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Immunotherapy a New Hope for Cancer Treatment: A Review Publisher Pubmed



Rouzbahani FN1 ; Shirkhoda M1 ; Memari F1 ; Dana H1, 2 ; Chalbatani GM1 ; Mahmoodzadeh H1 ; Samarghandi N3 ; Gharagozlou E1 ; Hadloo MHM4 ; Maleki AR1 ; Sadeghian E1 ; Nia EZ2 ; Nia N5 ; Hadjilooei F1 Show All Authors
Authors
  1. Rouzbahani FN1
  2. Shirkhoda M1
  3. Memari F1
  4. Dana H1, 2
  5. Chalbatani GM1
  6. Mahmoodzadeh H1
  7. Samarghandi N3
  8. Gharagozlou E1
  9. Hadloo MHM4
  10. Maleki AR1
  11. Sadeghian E1
  12. Nia EZ2
  13. Nia N5
  14. Hadjilooei F1
  15. Rezaeian O6
  16. Meghdadi S6
  17. Miri S1
  18. Jafari F7
  19. Rayzan E8
  20. Marmari V2
Show Affiliations
Authors Affiliations
  1. 1. Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran
  2. 2. Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
  3. 3. Depertment of Immunology, School of Medicine, University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  5. 5. Department of Biology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
  6. 6. Department of Biology, Nour Danesh Institute of Higher Education, Isfahan, Iran
  7. 7. Paramedical Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. International Hematology/Oncology of Pediatrics Experts, Universal Scientific Education and Research Network, Tehran University of Medical Sciences, Iran

Source: Pakistan Journal of Biological Sciences Published:2018


Abstract

Cancer is a major burden of disease worldwide with considerable impact on society. The tide of immunotherapy has finally changed after decades of disappointing results and has become a clinically validated treatment for many cancers. Immunotherapy takes many forms in cancer treatment, including the adoptive transfer of ex vivo activated T cells, oncolytic viruses, natural killer cells, cancer vaccines and administration of antibodies or recombinant proteins that either costimulate cells or block the so-called immune checkpoint pathways. Recently, cancer immunotherapy has received a high degree of attention, which mainly contains the treatments for programmed death ligand 1 (PD-L1), programmed death 1 (PD-1), chimeric antigen receptors (CARs) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). Here, this paper reviewed the current understandings of the main strategies in cancer immunotherapy (adoptive cellular immunotherapy, immune checkpoint blockade, oncolytic viruses and cancer vaccines) and discuss the progress in the synergistic design of immune-targeting combination therapies. © 2018 Fatemeh Nouri Rouzbahani et al.
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