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Fabrication of Poly Hydroxybutyrate-Polyethylene Glycol-Folic Acid Nanoparticles Loaded by Paclitaxel Publisher Pubmed



Rezaei F1 ; Rafienia M2 ; Keshvari H1 ; Sattary M3 ; Naeimi M4 ; Keyvani H5
Authors
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Authors Affiliations
  1. 1. Amirkabir University of Technology, Tehran, Iran
  2. 2. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Biomedical Engineering Department, Science and Research Branch Islamic Azad University, Tehran, Iran
  4. 4. Biomedical Engineering Department, Central Tehran Branch, Islamic Azad University, Tehran, Iran
  5. 5. Department of Virology, Iran University of Medical Science, Tehran, Iran

Source: Current Drug Delivery Published:2016


Abstract

In this study drug (paclitaxel)-loaded nanoparticles of poly hydroxybutyrate-polyethylene glycol-folic acid (PHB-PEG-FOL) were prepared by using an oil-in-water (O/W) emulsion-solvent evaporation method. The functionalization and conjugation steps in the chemical synthesis were confirmed using Fourier transform infrared (FTIR) and nuclear magnetic resonance tests (1H NMR). Morphology of nanoparticles was evaluated by scanning electron microscopy (SEM). Nanoparticles were characterized by particle size analyzer. Between two samples containing drug, the lower doses showed more homogeneous distribution, and the lowest aggregation. The drug release profiles showed a two-phase release including initial rapid release and a continuous release. MG63 cells were used to evaluate cytotoxicity. The cytotoxicity of PHB-PEG-FOL nanoparticles with drug against cancer cells was much higher and longer than free drug sample. These nanoparticles were successfully synthesized as a novel system for targeted drug delivery against cancer cells. © 2016 Bentham Science Publishers.
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