Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Bariatric Surgery in Migraine Patients: Cgrp Level and Weight Loss Publisher Pubmed



Etefagh HH1 ; Shahmiri SS2, 3, 4 ; Melali H5 ; Sayadi M6 ; Ansari H7 ; Shahzamani A8 ; Deyhimi MS1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Neurology, Alzahra University Hospital, School of Medicine, Isfahan University of Medical Sciences, Hezar Jerib Street, 81746-73461, Isfahan, Iran
  2. 2. Department of Surgery, Division of Minimally Invasive and Bariatric Surgery, Minimally Invasive Surgery Research Center, Rasool-E Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Center of Excellence of European Branch of International Federation for Surgery of Obesity, Hazrat_e Rasool Hospital, Tehran, Iran
  4. 4. Iran National Center of Excellence for Minimally Invasive Surgery Education, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Surgery, Amin Hospital, School of Medicine, Isfahan University of Medical Sciences, Hezar Jerib Street, Isfahan, Iran
  6. 6. Department of Surgery, Al-Zahra Hospital, School of Medicine, Isfahan University of Medical Sciences, Hezar Jerib Street, Isfahan, Iran
  7. 7. Department of Neuroscience, Kaizen Brain Center, University of California, San Diego, United States
  8. 8. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Obesity Surgery Published:2022


Abstract

Background: Obesity makes migraine more prevalent and severe. Serum level of calcitonin gene-related peptide (CGRP) is associated with the severity of migraine attacks. Although the effect of weight and bariatric surgery has been studied on migraine, the role of CGRP in migraine remission after weight loss surgery needs more investigation. Methods: Patients with severe obesity who were bariatric surgery candidates and had been diagnosed with chronic migraine were included in this study. Weight, BMI, number of days with headache in the past 3 months, and severity of headaches in 10-point Likert VAS, Migraine Disability Assessment Scale (MIDAS) and Migraine Specific Quality of life (MSQ) questionnaire scores, and serum CGRP levels were evaluated before and within 6–10 months after surgery. Result: Sixty patients with chronic migraine with severe obesity were included. Ninety-five percent of patients reported a significantly lower number of attacks (21 to 8, p < 0.001) and severity of headaches within 90-day (7.7 to 4.8, p < 0.001); MIDAS (64.4 to 25.5, p < 0.001) and MSQ scores (44.6 to 26.8, p < 0.001) and CGRP level (252.7 to 130.1, p < 0.001) were significantly reduced after surgery with a mean follow-up of 7.5 months. Changes in MIDAS, MSQ, and CGRP were significantly associated with weight-related variables. Conclusion: Bariatric surgery decreases the frequency of migraine attacks, lessens the severity of headaches, and improves the quality of life and disability as well as CGRP plasma levels, suggesting CGRP as a possible etiology in the migraine-obesity link. Graphical abstract: [Figure not available: see fulltext.] © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Related Docs
View other Related Docs
1. Associations Between Dietary Diversity Score and Migraine Headaches: The Results From a Cross-Sectional Study, Frontiers in Nutrition (2023)
2. Artificial Intelligence Analysis to Explore Synchronize Exercise, Cobalamin, and Magnesium As New Actors to Therapeutic of Migraine Symptoms: A Randomized, Placebo-Controlled Trial, Neurological Sciences (2022)
3. Comparison of the Severity, Duration and Frequency of Headaches Between Migraine Patients With and Without Metabolic Syndrome, Journal of Isfahan Medical School (2012)
4. The Association Between Abdominal Obesity and Characteristics of Migraine Attacks in Iranian Adults, Iranian Journal of Nursing and Midwifery Research (2016)
5. The Association Between Anthropometric Measurements and Severity, Frequency and Duration of Headache Attacks in Adults With Migraine in Isfahan, Journal of Mazandaran University of Medical Sciences (2014)
6. Metabolic Syndrome in Migraine Headache: A Case-Control Study, Journal of Research in Medical Sciences (2014)
7. The Beneficial Effect of Alpha-Lipoic Acid Supplementation As a Potential Adjunct Treatment in Episodic Migraines, Scientific Reports (2022)
8. Associations Between Diet Quality and Migraine Headaches: A Cross-Sectional Study, Nutritional Neuroscience (2024)
Experts (# of related papers)
View all Related Experts
Gholamreza Askari (25)
Fariborz Khorvash (23)
Other Related Docs
9. Relationship Between Vitamin D Receptor Gene Polymorphisms and Migraine Without Aura in an Iranian Population, BioMed Research International (2013)
10. The Effects of Concurrent Coenzyme Q10, L-Carnitine Supplementation in Migraine Prophylaxis: A Randomized, Placebo-Controlled, Double-Blind Trial, Cephalalgia (2019)
11. Practical Supplements for Prevention and Management of Migraine Attacks: A Narrative Review, Frontiers in Nutrition (2024)
12. Associations Between Adherence to Mediterranean Dietary Pattern and Frequency, Duration, and Severity of Migraine Headache: A Cross-Sectional Study, Nutritional Neuroscience (2023)
13. The Association Between Obesity and Migraine in a Population of Iranian Adults: A Case-Control Study, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2018)
14. Epidemiologic and Clinical Characteristics of Migraine Headaches: A Descriptive Study in Isfahan, Iran, Journal of Isfahan Medical School (2012)
15. The Association Between Multiple Sclerosis and Migraine: A Meta-Analysis, Multiple Sclerosis and Related Disorders (2023)
16. Effects of Probiotic and Vitamin D Co-Supplementation on Clinical Symptoms, Mental Health, and Inflammation in Adult Patients With Migraine Headache: A Randomized, Triple-Blinded, Placebo-Controlled Trial, BMC Medicine (2024)
17. The Effect of Psychosocial Group-Therapy on Improvement of Migraine Attacks and Quality of Life of Patients With Migraine, Journal of Isfahan Medical School (2015)
18. Effect of Vitamin D Supplementation on Symptoms and C-Reactive Protein in Migraine Patients, Journal of Research in Medical Sciences (2015)
19. Association Between Dietary Acid Load and Clinical Features of Migraine Headaches Among Iranian Individuals, Scientific Reports (2022)
20. The Effects of the Dietary Approaches to Stop Hypertension (Dash) Diet on Oxidative Stress and Clinical Indices of Migraine Patients: A Randomized Controlled Trial, Nutritional Neuroscience (2022)
21. Associations Between Potential Inflammatory Properties of the Diet and Frequency, Duration, and Severity of Migraine Headaches: A Cross-Sectional Study, Scientific Reports (2022)
22. Effect of Soy Isoflavones Supplementation on Migraine Characteristics, Mental Status and Calcitonin Gene-Related Peptide (Cgrp) Levels in Women With Migraine: Results of Randomised Controlled Trial, Nutrition Journal (2022)
23. The Psychometric Properties of the Persian Migraine-Specific Quality of Life Questionnaire Version 2.1 in Episodic and Chronic Migraines, The Scientific World Journal (2013)
24. Is There a Link Between the Inflammatory Potential of a Diet and Mental Health Among Patients With Migraine? Findings From a Cross-Sectional Survey, Nutritional Neuroscience (2024)
25. Effect of Zinc Supplementation on Symptoms and C-Reactive Protein Among Patients With Migraine: A Double-Blind Randomized Placebo-Controlled Clinical Trial, Journal of Health System Research (2020)
26. The Association Between Serum Vitamin D Levels With General and Abdominal Obesity Among Patients With Migraine, International Journal of Preventive Medicine (2013)
27. The Predictive Role of the Dietary Phytochemical Index in Relation to the Clinical and Psychological Traits of Migraine Headaches, Scientific Reports (2024)
28. Thr698thr (Nt2369) Polymorphism on Cacna1a Gene and Head Pain Severity in Familial Migraine, Journal of Research in Medical Sciences (2013)
29. The Association Between Plant Protein Sources and Migraine Symptoms: A Case-Control Study Among Iranian Adults, Journal of Health System Research (2024)
30. Effects of Co-Supplementation With Alpha-Linolenic Acid and L-Carnitine on Inflammatory Status and Oxidative Stress in Women With Migraine: A Randomized, Triple-Blind, Placebo-Controlled Trial, Journal of Functional Foods (2024)
31. Effects of the Dietary Approaches to Stop Hypertension (Dash) Diet on Clinical, Quality of Life and Mental Health Outcomes in Women With Migraine: A Randomised Controlled Trial, British Journal of Nutrition (2022)
32. The Association Between Adherence to Alternative Healthy Diet Index (Ahei) and Severity, Disability, Duration, and Frequency of Migraine Headache Among Women: A Cross-Sectional Study, Nutrition Journal (2023)
33. Effects of Curcumin Supplementation on Clinical Features and Inflammation, in Migraine Patients: A Double-Blind Controlled, Placebo Randomized Clinical Trial, International Journal of Preventive Medicine (2021)
34. Is There an Association Between a Plant-Based Eating Pattern and Clinical Findings of a Migraine Headache?, Frontiers in Nutrition (2023)
35. Effects of Cinnamon on Anthropometric Indices and Headache-Related Disability of Patients With Migraine: A Randomized Double-Blind Placebo-Controlled Trial, Avicenna Journal of Phytomedicine (2024)