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Is There a Link Between the Inflammatory Potential of a Diet and Mental Health Among Patients With Migraine? Findings From a Cross-Sectional Survey Publisher Pubmed



Navab FS1 ; Hadi A2 ; Jahlan I3 ; Askari G4 ; Khorvash F5 ; Arab A6, 7
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Authors Affiliations
  1. 1. Student Research Committee, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Halal Research Center of IRI, Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran
  3. 3. Maternal and Child Health Nursing Department, King Saud University, Riyadh, Saudi Arabia
  4. 4. Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Division of Sleep Medicine, Harvard Medical School, Boston, MA, United States
  7. 7. Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women’s Hospital, Boston, MA, United States

Source: Nutritional Neuroscience Published:2024


Abstract

Aims: In this study, we aimed to evaluate the relationship between the dietary inflammatory index (DII) and mental health outcomes among patients with migraine headaches. Methods: In this cross-sectional study, 262 subjects were included. The dietary intakes were collected using a validated 168-item semi-quantitative food frequency questionnaire. Items were scored according to their inflammatory potential, so a higher DII indicated a more pro-inflammatory diet. The association between DII and the mental health of participants was investigated using multinomial logistic regression and odds ratio (OR) with a corresponding 95% confidence interval (CI) was reported. Results: Overall, 224 women and 38 men, with a mean (standard error) DII of −2.96 (0.06), age of 36.1 (0.53) years, and BMI of 25.55 (0.21) kg/m2, comprised our study population. DII was positively associated with a higher risk of depression in patients with the highest adherence to a pro-inflammatory diet compared to those with the lowest adherence (OR = 1.76; 95%CI: 1.04, 3.00; Ptrend= 0.035). Adjustments for age, sex, marital status, smoking status, migraine headache index score, number of family members, mean arterial pressure, medication, physical activity, and BMI intensified the association in a way that the risk of depression was 2.03 times higher in patients with the highest adherence to a pro-inflammatory diet compared to those with the lowest adherence to a pro-inflammatory diet (OR = 2.03; 95%CI: 1.18, 3.49; Ptrend= 0.011). Conclusion: Our findings suggest that depression was positively associated with adherence to a pro-inflammatory diet. However, no significant association was observed between anxiety and stress with DII. © 2024 Informa UK Limited, trading as Taylor & Francis Group.
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