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Effects of Losartan on Capillary Density in Cardiac Muscles of Diabetic Rats



Fallahzadeh AR1 ; Afsharmoghaddam N2 ; Khazaei M3
Authors
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Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
  2. 2. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2012

Abstract

Background: Stimulatory and/or inhibitory effects of angiotensin II is attributed to angiotensin receptor I. A few studies investigated the role of angiotensin receptor I on cardiovascular system in diabetic subjects. In this study, we evaluated the effects of losartan, an angiotensin II receptor I blocker, on myocardial capillary density in diabetic rats. Methods: A total number of 18 male rats were divided into 3 groups of control, diabetic, and diabetic receiving losartan. Diabetes was induced by intraperitoneal injection of streptozotocin (55 mg/kg). A daily dose of 15 mg/kg intraperitoneal losartan was injected to the treatment group. After 21 days, blood samples were taken and myocardial tissue was evaluated by immunohistochemistry. Findings: Myocardial capillary density in diabetic animals was lower than the control group (P < 0.05). Losartan could not significantly change capillary density in myocardial tissue of the diabetic rats (P > 0.05). Conclusion: It seems that losartan administration does not have beneficial effects on myocardial capillary density in diabetic animals.
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