Advances in Nanotechnology Versus Stem Cell Therapy for the Theranostics of Huntington's Disease

Advances in Nanotechnology Versus Stem Cell Therapy for the Theranostics of Huntington's Disease Publisher

Mustafa G¹ ; Hassan D¹ ; Zeeshan M^{2, 3} ; Ruizpulido G¹ ; Ebrahimi N⁴ ; Mobashar A⁵ ; Pourmadadi M⁶ ; Rahdar A⁷ ; Sargazi S^{8, 9} ; Fathikarkan S^{10, 11} ; Medina DI¹³ ; Diezpascual AM¹²

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1. Tecnologico de Monterrey, School of Engineering and Sciences, Atizapan de Zaragoza, Estado de Mexico, 52926, Mexico
2. Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan
3. Faculty of Pharmacy, Capital University of Science and Technology, Islamabad, Pakistan
4. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5. Department of Pharmacology, Faculty of Pharmacy, University of Lahore, Lahore, Pakistan
6. Department of Biotechnology, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
7. Department of Physics, Faculty of Science, University of Zabol, Zabol, 538-98615, Iran
8. Cellular and Molecular Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, 98167-43463, Iran
9. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
10. Department of Advanced Sciences and Technologies in Medicine, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, 9414974877, Iran
11. Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, 94531-55166, Iran
12. Universidad de Alcala, Facultad de Ciencias, Departamento de Quimica Analitica, Quimica Fisica e Ingenieria Quimica, Ctra. Madrid-Barcelona, Km. 33.6, Alcala de Henares, Madrid, 28805, Spain
13. Tecnologico de Monterrey, Institute of Advanced Materials for Sustainable Manufacturing, Nuevo Leon, Monterrey, 64849, Mexico

Source: Journal of Drug Delivery Science and Technology Published:2023

Abstract

Huntington's disease (HD) is a neurological disorder characterized by a reduction in medium-spiny neurons in the brain. Currently, there is no cure for HD and treatment relies on symptomatic therapy. The generation of stem cells, including neural, mesenchymal, and pluripotent, through conventional strategies or direct cell reprogramming, has revolutionized HD therapy research. Due to their unique ability to differentiate into a variety of cells, self-renew and grow, stem cells have become an area of interest for treating various complex and unresolved neurodegenerative disorders. Nanotechnology has emerged as a novel approach with great potential for treating HD with reduced side effects. Nanoparticles (NPs) can act as nanovehicles for delivering therapeutic agents, including siRNAs, stem cells, neurotrophic factors, and different drugs. Additionally, NPs can be used as an alternative treatment based on their antioxidant and reactive oxygen species -scavenging properties that protect neuronal cells. Some NPs even exhibit the ability to interfere with the protein aggregation of mutant Huntingtin proteins during neurodegenerative processes. This review focuses on the most studied NPs for treating HD, including polymeric, lipid-based, liposomes, solid lipid and metal/metal oxide NPs. The combination of NPs with stem cell therapy has great potential for neurodegenerative disease diagnosis and treatment. NPs have been used to manage the cellular microenvironment, improve the efficiency of cell and drug delivery to the brain, and enhance stem cell transplant survival. Understanding the characteristics of the different NPs is essential for applying them for therapeutic purposes. In this study, the biology of HD as well as the benefits and drawbacks of using NPs and stem cell therapy for its treatment are discussed. © 2023 The Authors

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Style	Citing Format
MLA	Mustafa G, et al.. "Advances in Nanotechnology Versus Stem Cell Therapy for the Theranostics of Huntington's Disease." Journal of Drug Delivery Science and Technology, vol. 87, no. , 2023, pp. -.
APA	Mustafa G, Hassan D, Zeeshan M, Ruizpulido G, Ebrahimi N, Mobashar A, Pourmadadi M, Rahdar A, Sargazi S, Fathikarkan S, Medina DI, Diezpascual AM (2023). Advances in Nanotechnology Versus Stem Cell Therapy for the Theranostics of Huntington's Disease. Journal of Drug Delivery Science and Technology, 87(), -.
Chicago	Mustafa G, Hassan D, Zeeshan M, Ruizpulido G, Ebrahimi N, Mobashar A, Pourmadadi M, et al.. "Advances in Nanotechnology Versus Stem Cell Therapy for the Theranostics of Huntington's Disease." Journal of Drug Delivery Science and Technology 87, no. (2023): -.
Harvard	Mustafa G et al. (2023) 'Advances in Nanotechnology Versus Stem Cell Therapy for the Theranostics of Huntington's Disease', Journal of Drug Delivery Science and Technology, 87(), pp. -.
Vancouver	Mustafa G, Hassan D, Zeeshan M, Ruizpulido G, Ebrahimi N, Mobashar A, et al.. Advances in Nanotechnology Versus Stem Cell Therapy for the Theranostics of Huntington's Disease. Journal of Drug Delivery Science and Technology. 2023;87():-.
BibTex	@article{ author = {Mustafa G and Hassan D and Zeeshan M and Ruizpulido G and Ebrahimi N and Mobashar A and Pourmadadi M and Rahdar A and Sargazi S and Fathikarkan S and Medina DI and Diezpascual AM}, title = {Advances in Nanotechnology Versus Stem Cell Therapy for the Theranostics of Huntington's Disease}, journal = {Journal of Drug Delivery Science and Technology}, volume = {87}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Mustafa G AU - Hassan D AU - Zeeshan M AU - Ruizpulido G AU - Ebrahimi N AU - Mobashar A AU - Pourmadadi M AU - Rahdar A AU - Sargazi S AU - Fathikarkan S AU - Medina DI AU - Diezpascual AM TI - Advances in Nanotechnology Versus Stem Cell Therapy for the Theranostics of Huntington's Disease JO - Journal of Drug Delivery Science and Technology VL - 87 IS - SP - EP - PY - 2023 ER -

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