Plant-Mediated Synthesis of Sphalerite (Zns) Quantum Dots, Th1-Th2 Genes Expression and Their Biomedical Applications

Plant-Mediated Synthesis of Sphalerite (Zns) Quantum Dots, Th1-Th2 Genes Expression and Their Biomedical Applications Publisher

Mohammad WT¹ ; Alijani H² ; Faris P^{3, 4} ; Salarkia E⁵ ; Naderifar M⁶ ; Akbarizadeh MR⁶ ; Hashemi N⁷ ; Iravani S⁸ ; Jalil AT⁹ ; Saleh MM^{10, 11} ; Fathi AH¹² ; Khatami M¹³

Show Affiliations

1. Princess Aisha Bint Al Hussein College for Nursing and Health Sciences, Princess Aisha College, Al-Hussein Bin Talal University, Jordan
2. Department of Biotechnology, Shahid Bahonar University of Kerman, Kerman, Iran
3. Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, 44001, Iraq
4. Department of Biology, Cihan University-Erbil, Erbil, 44001, Iraq
5. Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
6. Amir Al Momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran
7. School of Medicine, Bam University of Medical Sciences, Bam, Iran
8. Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
9. Medical Laboratories Techniques Department, Al-Mustaqbal University College, Hilla, Babylon, 51001, Iraq
10. Department of Biophysics, College of Applied Sciences, University of Anbar, Iraq
11. Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq
12. Department of Prosthodontics, Dental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
13. Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Source: South African Journal of Botany Published:2023

Abstract

Zinc sulfide (ZnS) quantum dots (QDs) have been widely explored for various industrial and medical applications owning to their unique properties. In this study, ZnS QDs were eco-friendly synthesis using green tea extract (GteaE). The properties of the QDs were evaluated by X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM), high-resolution transmission electron microscopy (HRTEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), differential thermal analysis (DTA), energy dispersive X-ray spectroscopy (EDAX), X-ray photoelectron spectroscopy (XPS), and Fourier-transform infrared spectroscopy (FTIR). Then, the cytotoxicity and apoptosis of ZnS QDs was studied based on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay against Leishmania major promastigotes and macrophages. At the used concentrations of ZnS QDs, cytotoxicity examination revealed no lethal effect as the selectivity index (SI) was within the safety range (SI = CC50/IC50 ≥1). The SI for GteaE was 10.52 and ZnS QDs was 6.61. ZnS QDs exhibited higher efficacy, better biocompatibility, and eco-friendly advantages compared to meglumine antimoniate (MA) leishmaniasis drug. The gene expression profiles of Th1 and Th2 genes studied. A significant upsurge of Th1 subsets and transcription genes and a meaningful decline in Th2 cytokines subclasses at the equivalent concentrations was observed (P < 0.001). The ZnS QDs treatment provide a valuable source of potential bioactive agents for antileishmanial drug development in patients with Cutaneous leishmaniasis (CL) in future clinical settings. © 2023 SAAB

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Style	Citing Format
MLA	Mohammad WT, et al.. "Plant-Mediated Synthesis of Sphalerite (Zns) Quantum Dots, Th1-Th2 Genes Expression and Their Biomedical Applications." South African Journal of Botany, vol. 155, no. , 2023, pp. 127-139.
APA	Mohammad WT, Alijani H, Faris P, Salarkia E, Naderifar M, Akbarizadeh MR, Hashemi N, Iravani S, Jalil AT, Saleh MM, Fathi AH, Khatami M (2023). Plant-Mediated Synthesis of Sphalerite (Zns) Quantum Dots, Th1-Th2 Genes Expression and Their Biomedical Applications. South African Journal of Botany, 155(), 127-139.
Chicago	Mohammad WT, Alijani H, Faris P, Salarkia E, Naderifar M, Akbarizadeh MR, Hashemi N, et al.. "Plant-Mediated Synthesis of Sphalerite (Zns) Quantum Dots, Th1-Th2 Genes Expression and Their Biomedical Applications." South African Journal of Botany 155, no. (2023): 127-139.
Harvard	Mohammad WT et al. (2023) 'Plant-Mediated Synthesis of Sphalerite (Zns) Quantum Dots, Th1-Th2 Genes Expression and Their Biomedical Applications', South African Journal of Botany, 155(), pp. 127-139.
Vancouver	Mohammad WT, Alijani H, Faris P, Salarkia E, Naderifar M, Akbarizadeh MR, et al.. Plant-Mediated Synthesis of Sphalerite (Zns) Quantum Dots, Th1-Th2 Genes Expression and Their Biomedical Applications. South African Journal of Botany. 2023;155():127-139.
BibTex	@article{ author = {Mohammad WT and Alijani H and Faris P and Salarkia E and Naderifar M and Akbarizadeh MR and Hashemi N and Iravani S and Jalil AT and Saleh MM and Fathi AH and Khatami M}, title = {Plant-Mediated Synthesis of Sphalerite (Zns) Quantum Dots, Th1-Th2 Genes Expression and Their Biomedical Applications}, journal = {South African Journal of Botany}, volume = {155}, number = {}, pages = {127-139}, year = {2023} }
RIS	TY - JOUR AU - Mohammad WT AU - Alijani H AU - Faris P AU - Salarkia E AU - Naderifar M AU - Akbarizadeh MR AU - Hashemi N AU - Iravani S AU - Jalil AT AU - Saleh MM AU - Fathi AH AU - Khatami M TI - Plant-Mediated Synthesis of Sphalerite (Zns) Quantum Dots, Th1-Th2 Genes Expression and Their Biomedical Applications JO - South African Journal of Botany VL - 155 IS - SP - 127 EP - 139 PY - 2023 ER -

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