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Cytotoxicity Properties of Plant-Mediated Synthesized K-Doped Zno Nanostructures Publisher Pubmed



Haghighat M1 ; Alijani HQ2 ; Ghasemi M3 ; Khosravi S3 ; Borhani F4 ; Sharifi F5 ; Iravani S6 ; Najafi K3, 7 ; Khatami M3, 8
Authors
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Authors Affiliations
  1. 1. Behbahan Faculty of Medical Sciences, Behbahan, Iran
  2. 2. Department of Biotechnology, Shahid Bahonar University of Kerman, Kerman, Iran
  3. 3. Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
  4. 4. Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
  6. 6. Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Source: Bioprocess and Biosystems Engineering Published:2022


Abstract

In this study, potassium-doped zinc oxide nanoparticles (K-doped ZnO NPs) were green-synthesized using pine pollen extracts based on bioethics principles. The synthesized NPs were analyzed using X-ray diffraction (XRD), inductively coupled plasma atomic emission spectroscopy (ICP-AES), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDXA), and transmission electron microscopy (TEM). The cytotoxicity of these nanoparticles (NPs) on normal macrophage cells and cancer cell lines was evaluated. In the same concentrations of K-doped ZnO and pure ZnO NPs, K-doped ZnO NPs demonstrated higher toxicity. The results confirmed that the doped potassium could increase cytotoxicity. The IC50 of K-doped ZnO NPs, pure ZnO NPs, and the examined control drug were 497 ± 15, 769 ± 12, and 606 ± 19 µg/mL, respectively. Considering the obtained IC50 of K-doped ZnO NPs, they were more toxic to the cancer cell lines and had less cytotoxicity on normal macrophage cells. Graphic abstract: [Figure not available: see fulltext.] © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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