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Biosynthesis of Core–Shell Α-Fe2o3@Au Nanotruffles and Their Biomedical Applications Publisher



Alijani HQ1 ; Fathi A2 ; Amin HIM3, 4 ; Lima Nobre MA5 ; Akbarizadeh MR6 ; Khatami M7 ; Jalil AT8 ; Naderifar M6 ; Dehkordi FS9 ; Shafiee A10
Authors
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Authors Affiliations
  1. 1. Department of Biotechnology, Shahid Bahonar University of Kerman, Kerman, Iran
  2. 2. Department of Prosthodontics, Dental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Chemistry, College of Science, Salahaddin University-Erbil, Erbil, 44001, Iraq
  4. 4. Department of Medical Biochemical Analysis, Cihan University-Erbil, Erbil, Iraq
  5. 5. Department of Physics, School of Technology and Sciences, Sao Paulo State University – UNESP Presidente Prudente Brazil, Sao Paulo, Brazil
  6. 6. Amir Al Momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran
  7. 7. Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  8. 8. Department of Medical Laboratories Techniques, Al-Mustaqbal University College, Hilla, Babylon, 51001, Iraq
  9. 9. Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  10. 10. Department of Chemistry, Cape Breton University, Sydney, B1P 6L2, NS, Canada

Source: Biomass Conversion and Biorefinery Published:2024


Abstract

Core/shell Fe@Au nanostructures with their unique physicochemical properties have been widely studied in a wide variety of biomedical programs, such as imaging, biosensing, hyperthermia, drug delivery, and tissue engineering. Core/shell hematite (α-Fe2O3)@Au nanotruffles were synthesized using Rosmarinus officinalis leaf extract as natural reducing agent. First, hematite (α-Fe2O3) nanoparticles were fabricated using phenolic compounds in rosemary extract. Then, the Au nanoparticles were coated on the α-Fe2O3 core nanoparticles without utilizing any intermediate material. The physicochemical properties of the Fe2O3@Au nanotruffles were evaluated by XRD, FTIR, FESEM-EDAX, HR-TEM, and XPS. Due to the specific morphology of Fe2O3@Au nanotruffles, the Au shell thickness varied from 2.3 to 9 nm in different regions. The toxicity of the core/shell α-Fe2O3@Au nanotruffles with different concentrations was evaluated on human glioblastoma U87 cancer and PC12 pheochromocytoma cells based on MTT assay. The results established that these nanotruffles had the high toxicity effect on glioblastoma cells at a concentration of 500 μg/mL. Additionally, their antibacterial was evaluated on Escherichia coli and Streptococcus mutans by using the dilution method. Graphical Abstract: (Figure presented.) © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.
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