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Influence of Carrier Particle Size, Carrier Ratio and Addition of Fine Ternary Particles on the Dry Powder Inhalation Performance of Insulin-Loaded Plga Microcapsules Publisher



Hamishehkar H1 ; Emami J2 ; Najafabadi AR3 ; Gilani K3 ; Minaiyan M2 ; Mahdavi H4 ; Nokhodchi A5
Authors
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Authors Affiliations
  1. 1. Pharmaceutical Technology Laboratory, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Aerosol Research Laboratory, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Novel Drug Delivery Systems, Iran Polymer and Petrochemical Institute, Tehran, Iran
  5. 5. Medway School of Pharmacy, The Universities of Kent and Greenwich, Chatham Maritime, ME4 4TB, Kent, Central Ave., United Kingdom

Source: Powder Technology Published:2010


Abstract

The effects of carrier particle size, carrier ratio and addition of fine ternary agents on dry powder inhalation performance of insulin-loaded PLGA microcapsules were investigated. The use of mannitol with larger particle size in the lower carrier/microcapsules ratio led to higher deposition profiles of the drug. The fine spray dried mannitol and spray dried leucine as the ternary agents both decreased the deposition and dispersibility of microcapsules. It was concluded that addition of ternary component does not always improve aerosolization properties of DPI formulations. Carrier particle size, its flowability and carrier-drug ratio were shown to play an important role in DPI formulations. © 2010 Elsevier B.V.
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