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Deoxyribonucleic Acid and Bovine Serum Albumin Interaction With the Asymmetric Schiff Base Ligand and Its Molybdenum (Vi) Complex: Multi Spectroscopic and Molecular Docking Studies Publisher



Khosravi I1 ; Sahihi M2 ; Dashtbani M2 ; Rudbari HA2 ; Borhan G3
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Qeshm Branch, Islamic Azad University, Qeshm, Iran
  2. 2. Department of Chemistry, University of Isfahan, Isfahan, Iran
  3. 3. Clinical Laboratory, Isfahan University of Medical Science, Isfahan, Iran

Source: Journal of Macromolecular Science, Part B: Physics Published:2017


Abstract

The interaction of an asymmetric Schiff base ligand derived from allylamine and 2,3-dihydroxybenzaldehyde and its molybdenum (VI) complex with deoxyribonucleic acid (DNA) and bovine serum albumin (BSA) were studied using spectroscopic and molecular docking methods. The spectroscopic results revealed that the DNA and BSA affinity for binding the Mo(VI) complex is greater than its ligand. Furthermore, the molecular docking calculations showed that H-bond, hydrophobic, π-π and π-cation interactions had the dominant roles in the stability of the compound-BSA complexes. The DNA interaction results suggested that the compounds interacted with DNA by the groove binding mechanism. © 2017 Taylor & Francis Group, LLC.
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