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The Role of Bcg in Human Immune Responses Induced by Multiple Injections of Autoclaved Leishmania Major As a Candidate Vaccine Against Leishmaniasis Publisher Pubmed



Alimohammadian MH1 ; Khamesipour A2 ; Darabi H1 ; Firooz A2 ; Malekzadeh S1 ; Bahonar A3 ; Dowlati Y2 ; Modabber F4
Authors
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Authors Affiliations
  1. 1. Department of Immunology, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Center for Research and Training In Skin Diseases and Leprosy, University of Medical Sciences, Tehran 14166, P.O. Box 14155-6383, Iran
  3. 3. Health Center of Aran-Bidgol, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Infectious Disease Research Institute, Seattle, WA 98104, 1124 Columbia Street, United States

Source: Vaccine Published:2002


Abstract

To determine if BCG was required in booster injections for autoclaved Leishmania major (ALM) vaccine, 75 volunteers with no response to leishmanin were injected double-blind and randomly with either ALM+BCG or BCG alone for the first injection and boosted either with ALM+BCG, ALM or BCG alone for the second and third. Addition of BCG to the boosters significantly increased the frequency and the magnitude of leishmanin skin tests (LSTs); however, there was no difference in proliferative and IFN-γ responses (a month and a year later). Three injections of BCG produced no observable adverse reaction; hence BCG could be used in booster injections to increase the protective potential of this candidate vaccine. © 2002 Elsevier Science Ltd. All rights reserved.
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