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The Role of Bcg in Human Immune Responses Induced by Multiple Injections of Autoclaved Leishmania Major As a Candidate Vaccine Against Leishmaniasis Publisher Pubmed



Alimohammadian MH1 ; Khamesipour A2 ; Darabi H1 ; Firooz A2 ; Malekzadeh S1 ; Bahonar A3 ; Dowlati Y2 ; Modabber F4
Authors

Source: Vaccine Published:2002


Abstract

To determine if BCG was required in booster injections for autoclaved Leishmania major (ALM) vaccine, 75 volunteers with no response to leishmanin were injected double-blind and randomly with either ALM+BCG or BCG alone for the first injection and boosted either with ALM+BCG, ALM or BCG alone for the second and third. Addition of BCG to the boosters significantly increased the frequency and the magnitude of leishmanin skin tests (LSTs); however, there was no difference in proliferative and IFN-γ responses (a month and a year later). Three injections of BCG produced no observable adverse reaction; hence BCG could be used in booster injections to increase the protective potential of this candidate vaccine. © 2002 Elsevier Science Ltd. All rights reserved.
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