Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Non-Viral Delivery Systems for Breast Cancer Gene Therapy Publisher Pubmed



Vaseghi G1 ; Rafiee L2 ; Javanmard SH2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medicine Sciences, Isfahan, Iran
  2. 2. Applied Physiology Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Current Gene Therapy Published:2017


Abstract

Introduction: The ever-evolving field of gene therapy promises several innovative treatments for cancer. Advances in genetic modification of tumor cells and micro environment have led to the development of more effective therapeutic strategies with fewer side effects. Materials & Methods: The development of effective delivery system challenges, remains. Non-viral vectors are interesting due to their bio-safety and their ability to transfer different types of nucleic acids. Examples of these techniques are the use of oligonucleoides, liposomes, nanoparticles, inorganic material, and engineered stem cells. Conclusion: In this review, we focus on recent advances in the intracellular delivery of DNA and siRNA to the cancer cells with emphasis on breast cancer. © 2017 Bentham Science Publishers.
Related Docs
View other Related Docs
1. Hollow Inorganic Nanoparticles As Efficient Carriers for Sirna Delivery: A Comprehensive Review, Current Pharmaceutical Design (2015)
2. Genetically Engineered Mesenchymal Stem Cells: Targeted Delivery of Immunomodulatory Agents for Tumor Eradication, Cancer Gene Therapy (2020)
3. Dual Protective and Cytotoxic Benefits of Mesenchymal Stem Cell Therapy in Combination With Chemotherapy/Radiotherapy for Cancer Patients, Critical Reviews in Eukaryotic Gene Expression (2015)
4. The Efficiency of Cd40 Down Regulation by Sirna and Antisense Odn: Comparison of Lipofectamine and Fugene6, Iranian Journal of Immunology (2009)
5. Application of Mesenchymal Stem Cells in Melanoma: A Potential Therapeutic Strategy for Delivery of Targeted Agents, Current Medicinal Chemistry (2016)
6. Evaluation of Cationic Dendrimer and Lipid As Transfection Reagents of Short Rnas for Stem Cell Modification, International Journal of Pharmaceutics (2013)
7. Lipoprotein Like Nanoparticles Used in Drug and Gene Delivery, Current Pharmaceutical Design (2016)
8. Nanoparticles for Targeted Delivery of Therapeutics and Small Interfering Rnas in Hepatocellular Carcinoma, World Journal of Gastroenterology (2015)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (16)
Mina Mirian (10)
Other Related Docs
9. Gene Delivery by Pei-Nanocomplex Into Breast and Colorectal Tumor Cell Lines, the Impacts of N/P Ratio, Size and Type of the Cell; [Pei-Nanocomplex Tarafindan Meme Ve Kolorektal Tumor Hucre Hatlarinda Gen Dagitimi, N / P Oraninin, Hucrenin Boyutu Ve Turunun Etkileri], Fabad Journal of Pharmaceutical Sciences (2020)
10. Recent Advancements to Engineer Mesenchymal Stem Cells and Their Extracellular Vesicles for Targeting and Destroying Tumors, Progress in Biophysics and Molecular Biology (2023)
11. In Vitro and in Vivo Evaluation of Novel Dtx-Loaded Multifunctional Heparin-Based Polymeric Micelles Targeting Folate Receptors and Endosomes, Recent Patents on Anti-Cancer Drug Discovery (2020)
12. Evaluation of in Vivo Transfection Efficiency of Eudragit Coated Nanoparticles of Chitosan-Dna: A Ph-Sensitive System Prepared for Oral Dna Delivery, Iranian Red Crescent Medical Journal (2015)
13. Boron Phenyl Alanine Targeted Ionic Liquid Decorated Chitosan Nanoparticles for Mitoxantrone Delivery to Glioma Cell Line, Pharmaceutical Development and Technology (2021)
14. Hyaluronic Acid Targeted Metal Organic Framework Based on Iron (Iii) for Delivery of Platinum Curcumin Cytotoxic Agent to Triple Negative Breast Cancer Cell Line, Applied Organometallic Chemistry (2022)
15. Co-Delivery of Dasatinib and Mir-30A by Liposomes Targeting Neuropilin-1 Receptors for Triple-Negative Breast Cancer Therapy, Journal of Materials Chemistry B (2024)
16. Selection and Characterization of Single-Stranded Dna Aptamers Binding Human B-Cell Surface Protein Cd20 by Cell-Selex, Molecules (2018)
17. As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice, Nanomedicine (2018)
18. Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors, Vaccines (2022)
19. Sirna and Epigenetic Aberrations in Ovarian Cancer, Journal of Cancer Research and Therapeutics (2016)
20. An Anticancer Effect of Umbilical Cord-Derived Mesenchymal Stem Cell Secretome on the Breast Cancer Cell Line, Cell and Tissue Banking (2019)
21. A Concise Review on Cancer Treatment Methods and Delivery Systems, Journal of Drug Delivery Science and Technology (2019)
22. Genetically Engineered Viral Vectors and Organic-Based Non-Viral Nanocarriers for Drug Delivery Applications, Advanced Healthcare Materials (2022)
23. Fabrication and Evaluation of a Dual-Targeting Nanoparticle Mediated Crispr/Cas9 Delivery to Combat Drug Resistance in Breast Cancer Cells, Journal of Drug Delivery Science and Technology (2023)
24. Dendrimers As Nanoscale Vectors: Unlocking the Bars of Cancer Therapy, Seminars in Cancer Biology (2022)
25. Nucleic Acid-Based Therapeutics for Dermal Wound Healing, International Journal of Biological Macromolecules (2022)
26. Sirna Delivery Improvement by Co-Formulation of Different Modified Polymers in Erythroleukemic Cell Line K562, Iranian Journal of Basic Medical Sciences (2013)
27. Multifunctional and Stimuli-Responsive Liposomes in Hepatocellular Carcinoma Diagnosis and Therapy, Translational Oncology (2024)
28. Recent Advances in Aptamer Discovery, Modification and Improving Performance, Biochemistry and Biophysics Reports (2024)
29. Camouflaged Liposomes by 11A4-Nanobody for Co-Delivery of Cisplatin and Nitroxoline in Breast Cancer Tumors: An in Vitro/In Vivo Study, Journal of Drug Delivery Science and Technology (2022)
30. The Therapeutic Potential of Human Adipose-Derived Mesenchymal Stem Cells Producing Cxcl10 in a Mouse Melanoma Lung Metastasis Model, Cancer Letters (2018)
31. Viral Nanoparticles-Mediated Delivery of Therapeutic Cargo, Advanced Therapeutics (2023)
32. Human Mesenchymal Stromal Cell Therapy for Prevention and Recovery of Chemo/Radiotherapy Adverse Reactions, Cytotherapy (2015)
33. Mesenchymal Stem Cells: A New Platform for Targeting Suicide Genes in Cancer, Journal of Cellular Physiology (2018)
34. Engineered Small Extracellular Vesicles As a Novel Platform to Suppress Human Oncovirus-Associated Cancers, Infectious Agents and Cancer (2023)
35. Co-Delivery of Paclitaxel and Α-Tocopherol Succinate by Novel Chitosan-Based Polymeric Micelles for Improving Micellar Stability and Efficacious Combination Therapy, Drug Development and Industrial Pharmacy (2015)
36. Plant-Derived Edible Nanoparticles and Mirnas: Emerging Frontier for Therapeutics and Targeted Drug-Delivery, ACS Sustainable Chemistry and Engineering (2019)
37. Lipid Nanocapsules for Imatinib Delivery: Design, Optimization and Evaluation of Anticancer Activity Against Melanoma Cell Line, Iranian Journal of Pharmaceutical Research (2019)
38. Synthesis and in Vitro Evaluation of Self-Assembling Biocompatible Heparin-Based Targeting Polymeric Micelles for Delivery of Doxorubicin to Leukemic Cells, Research in Pharmaceutical Sciences (2025)
39. The Mrna Vaccines and Their Application to Combat Infectious Diseases and Cancers: A Review Article, Journal of Isfahan Medical School (2023)
40. Her-2 Aptamer-Targeted Ecoflex® Nanoparticles Loaded With Docetaxel Promote Breast Cancer Cells Apoptosis and Anti-Metastatic Effect, IET Nanobiotechnology (2019)
41. Immobilized Nanoparticles-Mediated Enzyme Therapy; Promising Way Into Clinical Development, Discover Nano (2023)
42. Preparation and Evaluation of Targeted Albumin Lipid Nanoparticles With Lactobionic Acid for Targeted Drug Delivery of Sorafenib in Hepatocellular Carcinoma, Journal of Drug Delivery Science and Technology (2022)
43. As1411 Aptamer-Anionic Linear Globular Dendrimer G2-Iohexol Selective Nano-Theranostics, Scientific Reports (2017)
44. Hyaluronic Acid-Conjugated Gliadin Nanoparticles for Targeted Delivery of Usnic Acid in Breast Cancer: An in Vitro / in Vivo Translational Study, Journal of Drug Delivery Science and Technology (2023)
45. Genetically Modified Murine Adipose-Derived Mesenchymal Stem Cells Producing Interleukin-2 Favor B16f10 Melanoma Cell Proliferation, Immunological Investigations (2015)
46. Antibody-Drug Therapeutic Conjugates: Potential of Antibody-Sirnas in Cancer Therapy, Journal of Cellular Physiology (2019)
47. A Comprehensive Review on Novel Targeted Therapy Methods and Nanotechnology-Based Gene Delivery Systems in Melanoma, European Journal of Pharmaceutical Sciences (2023)
48. Piggybac As a Novel Vector in Cancer Gene Therapy: Current Perspective, Cancer Gene Therapy (2016)
49. Poly[N-(2-Aminoethyl)Ethyleneimine] As a New Non-Viral Gene Delivery Carrier: The Effect of Two Protonatable Nitrogens in the Monomer Unit on Gene Delivery Efficiency, Journal of Pharmacy and Pharmaceutical Sciences (2014)
50. Comparing the Transfection Efficiency of Cationic Monomer Ratios in Vinylimidazole and Aminoethyl Methacrylate Copolymers, International Journal of Pharmaceutics: X (2025)