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Effect of Targeted Gold Nanoparticles Size on Acoustic Cavitation: An in Vitro Study on Melanoma Cells Publisher Pubmed



Shanei A1 ; Akbarizadeh H1 ; Attaran N2 ; Salamat MR1 ; Baradaranghahfarokhi M3
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Medical Nanotechnology, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Medical Radiation Engineering, Faculty of Advanced Sciences & Technologies, Isfahan University, Isfahan, Iran

Source: Ultrasonics Published:2020


Abstract

When a liquid is irradiated with high intensities of ultrasound irradiation, acoustic cavitation occurs. Since cavitation can be fatal to cells, it is utilized to destroy cancer tumors. Considering cavitation onset and bubbles collapse, the required ultrasonic intensity threshold can be significantly decreased in the presence of nanoparticles in a liquid. The effects of gold nanoparticles size on acoustic cavitation were investigated in this in vitro study. For this purpose, ultrasonic waves were used at intensities of 0.5, 1 and 2 W/cm2 and frequency of 1 MHz in the presence of F-Cys-GNPs with 15, 23 and 79 nm sizes and different concentrations (0.2, 1 and 5 µg/ml) in order to determine their effects on the viability of melanoma cells. This was performed at different incubation times 12, 24 and 36 h. The viability of melanoma cells decreased at higher concentrations and sizes of F-Cys-GNPs. The lowest viability of melanoma cells was seen in those containing 79, 23, and 15 nm F-Cys-GNPs. This finding could be explained from the concept that the nucleation sites on the surface of GNPs increase with an increase in size of GNPs, which results in an increase in the number of cavitation bubbles. Acoustic cavitation in the presence of gold nanoparticles can be used as a way for improving therapeutic effects on the tumors. © 2020 Elsevier B.V.
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