Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Assessing Ptv Margins in Prostate Cancer Tomotherapy and Inter-Fractional Motion and Factors Impacting Ptv and Oar Displacement; [ارزیابی حاشیه های حجم هدف طراحی درمان در توموتراپی سرطان پروستات و جابجایی ارگان ها در بین جلسات درمانی و عوامل مؤثر بر جابجایی حجم هدف و ارگان های در معرض خطر] Publisher



Shabaninejad V1, 2, 4, 5 ; Shanei A1, 2, 4, 5 ; Roayaei M3 ; Akhavan A3 ; Saeb M1, 2, 4, 5 ; Hadinezhad S1, 2, 4, 5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Radiotherapy and Oncology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2024


Abstract

Background: Treatment planning target volume (PTV) motion in prostate cancer tomotherapy is an important challenge in treatment planning. This study aimed to evaluate PTV margins for prostate cancer tomotherapy. Methods: From 2021 to 2023, 20 patients with prostate cancer underwent tomotherapy. Before each treatment session, the MVCT image was taken from the patient, and the patient's settings were made using pelvic bone markers and tattoos. Before treatment, prostate volume was measured by ultrasound. Bladder volume was measured in MVCT images and compared with CTSim images. PTV displacements were measured and the required margin for 95% PTV dose was determined using the average prostate displacement. Correlation coefficients between bladder volume, prostate volume, and PTV displacement were calculated. Findings: This study analyzed a total of 497 MVCT and 20 CT images. Anisotropic PTV margins, accounting for random uncertainties, were 14-6.9 mm for PTV1, 11.4-6.2 mm for PTV2, and 5.9-3.5 mm for PTV3 in the anterior-posterior direction, respectively. Conclusion: This research reveals that a non-uniform PTV margin is needed to compensate for the random uncertainties caused by the movement of the prostate between tomotherapy sessions. Filling of the bladder and diet play a vital role in the displacement of the prostate. © 2024 Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Dosiomics-Based Detection of Dose Distribution Variations in Helical Tomotherapy for Prostate Cancer Patients: Influence of Treatment Plan Parameters, Physical and Engineering Sciences in Medicine (2024)
2. Evaluation of the Changes in the Shape and Location of the Prostate and Pelvic Organs Due to Bladder Filling and Rectal Distension, Iranian Red Crescent Medical Journal (2011)
3. Dosimetric and Radiobiological Evaluation of Multiparametric Mri-Guided Dose Painting in Radiotherapy of Prostate Cancer, Journal of Medical Signals and Sensors (2017)
4. Dosimetric Characteristics of Tomotherapy and Three-Dimensional Conformal Radiotherapy for Head and Neck Cancer, International Journal of Radiation Research (2023)
5. Development and Validation of Mcnpx-Based Monte Carlo Treatment Plan Verification System, Journal of Medical Physics (2015)
6. Nested Cnn Architecture for Three-Dimensional Dose Distribution Prediction in Tomotherapy for Prostate Cancer, Strahlentherapie und Onkologie (2025)
7. Whole-Body Low-Dose Ct Can Be of Value in Prostate Cancer Decision-Making: A Retrospective Study on 601 Patients, Insights into Imaging (2023)
8. Optimization of Ct Slice Thickness in 3D-Crt and Imrt Planning of Low Grade Glioma, International Journal of Radiation Research (2021)
Experts (# of related papers)
View all Related Experts
Daryoush Shahbazi-Gahrouei (7)
Ali Akhavan (4)
Other Related Docs
9. Predictors of Bone Metastasis in Pre-Treatment Staging of Asymptomatic Treatment-Naive Patients With Prostate Cancer, Revista Espanola de Medicina Nuclear e Imagen Molecular (2013)
10. The Comparison of Radiation Dosimetry of Rectal Cancer in Two Supine and Prone Positions, Journal of Isfahan Medical School (2023)
11. Evaluation of the Effects of Prostate Radiation Therapy on Occludin Expression and Ultrasonography Characteristics of the Bladder, International Journal of Radiation Oncology Biology Physics (2017)
12. Comparison of Fused Mri/Ct-Based Contouring and Ct-Based Contouring in Helical Tomotherapy for Rectal Cancer, Journal of Isfahan Medical School (2023)
13. Evaluation and Comparison of Target and At-Risk Organ Dosimetry in Radiation Therapy of Prostate Cancer Patients Using Three-Dimensional Conformal Radiotherapy (3D-Crt) and Intensity-Modulated Radiation Therapy (Imrt), Journal of Isfahan Medical School (2022)
14. Evaluation and Comparison of Various Treatment Plannings for Ovarian Cancer Involving the Abdominal Area, Journal of Isfahan Medical School (2016)
15. Comparison of Pet/Ct and Ct-Based Tumor Delineation and Its Effects on the Radiation Treatment Planning for Non-Small Cell Lung Cancer, Iranian Journal of Nuclear Medicine (2018)
16. The Effect of Contrast Media on Treatment Planning and Dose Calculation in Radiation Therapy of Pelvis Cancers, Journal of Isfahan Medical School (2017)
17. Evaluation of Targeted Image-Guided Radiation Therapy Treatment Planning System by Use of American Association of Physicists in Medicine Task Group-119 Test Cases, Journal of Medical Signals and Sensors (2018)
18. Comparison of Conventional Radiotherapy Techniques With Different Energies in Treating Prostate Cancer, Employing a Designed Pelvis Phantom, Journal of Medical Sciences (2008)
19. Dosiomics-Based Comparison of Dose Distributions in Nasopharyngeal Cancer Patients: 3D-Crt Versus Tomotherapy, International Journal of Radiation Research (2024)