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Exploring Metal-Organic Frameworks in Gene Delivery: From Prostate to Lung Therapeutics Publisher



Safarkhani M1 ; Dana N2 ; Taghavimandi F12 ; Najaflu M3 ; Esmaeili Y4 ; Zare EN5, 6 ; Huh YS1 ; Rahimmanesh I2 ; Makvandi P7, 8, 9 ; Xu Y10 ; Jin X11
Authors
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Authors Affiliations
  1. 1. Department of Biological Sciences and Bioengineering, Nano Bio High-Tech Materials Research Center, Inha University, 100 Inha-ro, Michuhol-gu, Incheon, 22212, South Korea
  2. 2. Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  4. 4. Biosensor Research Center, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  5. 5. School of Chemistry, Damghan University, Damghan, 36716-45667, Iran
  6. 6. Centre of Research Impact and Outreach, Chitkara University, Rajpura, Punjab, 140417, India
  7. 7. The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Zhejiang, Quzhou, 324000, China
  8. 8. Chitkara Centre for Research and Development, Chitkara University, Himachal Pradesh, 174103, India
  9. 9. University Centre for Research & Development, Chandigarh University, Punjab, Mohali, 140413, India
  10. 10. Department of Science & Technology, Department of Urology, NanoBioMed Group, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China
  11. 11. Department of Respiratory and Critical Care Medicine, NanoBioMed Group, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China
  12. 12. Nanomaterials and Surface Technology Research Laboratory, School of Chemical, Petroleum and Gas Engineering, Iran University of Science and Technology, P.B. 16765–163, Narmak, Tehran, Iran

Source: Applied Materials Today Published:2024


Abstract

Surfing the literature demonstrates that the emergence of gene delivery systems revolutionized the advancements in therapeutic interventions. These systems, broadly categorized as viral and non-viral vectors, offer distinct advantages. Although viral vectors exhibit high transfection efficiency, non-viral vectors present opportunities for customization and enhanced biosafety, making them versatile platforms for reliable gene delivery. In the case of non-viral vectors, nanotechnology has introduced transformative possibilities, specially by nanoparticle-based approaches. This comprehensive review focuses on Metal-Organic Frameworks (MOFs) as a main subset of non-viral nanocarriers with the purpose of gene delivery. MOFs, are well known due to their tunable structures and diverse functionalities, have garnered attention as a result of their adaptability in biomedical applications. Their unique characteristics like versatile chemical compositions, tunable pore sizes, and high surface/volume ratios, makes MOFs as reliable candidates as targeted gene delivery carriers which ensure biocompatibility besides high therapeutic encapsulation efficiency. This review explores the MOFs’ potential in gene delivery, emphasizing their comparative merits in comparison with other nanocarriers. The present article explores various aspects such as in vivo targeted delivery assessments, and MOFs' role in combination therapy. It is tried that each section comprehensively coverage the title and provide a coherent framework for underscoring MOFs' impact in advancing gene delivery strategies. © 2024 Elsevier Ltd
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