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Metal Nanoparticles and Carbohydrate Polymers Team up to Improve Biomedical Outcomes Publisher Pubmed



Falsafi SR1 ; Topuz F2 ; Bajer D3 ; Mohebi Z4 ; Shafieiuon M4 ; Heydari H5 ; Rawal S6, 7 ; Sathiyaseelan A8 ; Wang MH8 ; Khursheed R9 ; Enayati MH4 ; Rostamabadi H5
Authors
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Authors Affiliations
  1. 1. Safiabad Agricultural Research and Education and Natural Resources Center, Agricultural Research, Education and Extension Organization (AREEO), Dezful P.O. Box 333, Iran
  2. 2. Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Istanbul, Sariyer, 34469, Turkiye
  3. 3. Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, Torun, 87-100, Poland
  4. 4. Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  5. 5. Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  6. 6. Department of Pharmaceutical Technology, L.J. Institute of Pharmacy, L J University, Ahmedabad, 382210, India
  7. 7. Department of Pharmaceutics, Institute of Pharmacy, Nirma University, S.G. Highway, Chharodi, Gujarat, Ahmedabad, 382481, India
  8. 8. Department of Bio-Health Convergence, Kangwon National University, Chuncheon, 200-701, South Korea
  9. 9. School of Pharmaceutical Sciences, Lovely Professional University, Punjab, Phagwara, 144411, India

Source: Biomedicine and Pharmacotherapy Published:2023


Abstract

The convergence of carbohydrate polymers and metal nanoparticles (MNPs) holds great promise for biomedical applications. Researchers aim to exploit the capability of carbohydrate matrices to modulate the physicochemical properties of MNPs, promote their therapeutic efficiency, improve targeted drug delivery, and enhance their biocompatibility. Therefore, understanding various attributes of both carbohydrates and MNPs is the key to harnessing them for biomedical applications. The many distinct types of carbohydrate-MNP systems confer unique capabilities for drug delivery, wound healing, tissue engineering, cancer treatment, and even food packaging. Here, we introduce distinct physicochemical/biological properties of carbohydrates and MNPs, and discuss their potentials and shortcomings (alone and in combination) for biomedical applications. We then offer an overview on carbohydrate-MNP systems and how they can be utilized to improve biomedical outcomes. Last but not least, future perspectives toward the application of such systems are highlighted. © 2023 The Authors
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