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Insight Into The Cardioprotective Effects of Melatonin: Shining a Spotlight on Intercellular Sirt Signaling Communication Publisher Pubmed



Yaghoobi A1 ; Rezaee M1 ; Hedayati N2 ; Keshavarzmotamed A3 ; Khalilzad MA1 ; Russel R4 ; Asemi Z5 ; Rajabi Moghadam H6 ; Mafi A7, 8
Authors
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Authors Affiliations
  1. 1. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Iran University of Medical Science, Tehran, Iran
  3. 3. Student Research Committee, Guilan University of Medical Sciences, Rasht, Iran
  4. 4. Department of Cell Systems and Anatomy, UT Health. Long School of Medicine, San Antonio, TX, United States
  5. 5. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  6. 6. Department of Cardiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  7. 7. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Molecular and Cellular Biochemistry Published:2025


Abstract

Cardiovascular diseases (CVDs) are the leading causes of death and illness worldwide. While there have been advancements in the treatment of CVDs using medication and medical procedures, these conventional methods have limited effectiveness in halting the progression of heart diseases to complete heart failure. However, in recent years, the hormone melatonin has shown promise as a protective agent for the heart. Melatonin, which is secreted by the pineal gland and regulates our sleep–wake cycle, plays a role in various biological processes including oxidative stress, mitochondrial function, and cell death. The Sirtuin (Sirt) family of proteins has gained attention for their involvement in many cellular functions related to heart health. It has been well established that melatonin activates the Sirt signaling pathways, leading to several beneficial effects on the heart. These include preserving mitochondrial function, reducing oxidative stress, decreasing inflammation, preventing cell death, and regulating autophagy in cardiac cells. Therefore, melatonin could play crucial roles in ameliorating various cardiovascular pathologies, such as sepsis, drug toxicity-induced myocardial injury, myocardial ischemia–reperfusion injury, hypertension, heart failure, and diabetic cardiomyopathy. These effects may be partly attributed to the modulation of different Sirt family members by melatonin. This review summarizes the existing body of literature highlighting the cardioprotective effects of melatonin, specifically the ones including modulation of Sirt signaling pathways. Also, we discuss the potential use of melatonin-Sirt interactions as a forthcoming therapeutic target for managing and preventing CVDs. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
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