Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Melatonin and Non-Small Cell Lung Cancer: New Insights Into Signaling Pathways Publisher



Pourhanifeh MH1 ; Sharifi M2 ; Reiter RJ3 ; Davoodabadi A4 ; Asemi Z1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Department of Hematology and Oncology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Cellular and Structural Biology, University of Texas, Health Science Center, San Antonio, TX, United States
  4. 4. Departments of General Surgery, Trauma Research Center, Kashan University of Medical Sciences, Kashan, Iran

Source: Cancer Cell International Published:2019


Abstract

Non-small-cell lung cancer (NSCLC) is a type of malignancy with progressive metastasis having poor prognosis and lowered survival resulting from late diagnosis. The therapeutic approaches for the treatment of this incurable cancer are chemo- and radiotherapy. Since current treatments are insufficient and because of drug-induced undesirable side effects and toxicities, alternate treatments are necessary and critical. The role of melatonin, produced in and released from the pineal gland, has been documented as a potential therapy for NSCLC. Melatonin prevents tumor metastasis via inducing apoptosis processes and restraining the autonomous cell proliferation. Moreover, melatonin inhibits the progression of tumors due to its oncostatic, pro-oxidant and anti-inflammatory effects. As a result, the combined treatment with melatonin and chemotherapy may have a synergistic effect, as with some other tumors, leading to a prolonged survival and improved quality of life in patients with NSCLC. This review summarizes the available data, based on the molecular mechanisms and related signaling pathways, to show how melatonin and its supplementation function in NSCLC. © 2019 The Author(s).
Related Docs
View other Related Docs
1. Melatonin As a Regulator of Apoptosis in Leukaemia: Molecular Mechanism and Therapeutic Perspectives, Frontiers in Pharmacology (2023)
2. Melatonin and 5-Fluorouracil Combination Chemotherapy: Opportunities and Efficacy in Cancer Therapy, Cell Communication and Signaling (2023)
3. Molecular Basis of Melatonin Protective Effects in Metastasis: A Novel Target of Melatonin, Biochimie (2022)
4. Modulation of the Immune System by Melatonin; Implications for Cancer Therapy, International Immunopharmacology (2022)
5. Melatonin As a Promising Agent for Cancer Treatment: Insights Into Its Effects on the Wnt/Beta-Catenin Signaling Pathway, Current Medicinal Chemistry (2024)
6. Programmed Cell Death and Melatonin: A Comprehensive Review, Functional and Integrative Genomics (2024)
7. Melatonin Targeting Non-Coding Rnas in Cancer: Focus on Mechanisms and Potential Therapeutic Targets, European Journal of Pharmacology (2023)
8. Insight Into The Cardioprotective Effects of Melatonin: Shining a Spotlight on Intercellular Sirt Signaling Communication, Molecular and Cellular Biochemistry (2025)
Experts (# of related papers)
View all Related Experts
Mehran Sharifi (9)
Azadeh Moghaddas (3)
Other Related Docs
9. Melatonin for Gastric Cancer Treatment: Where Do We Stand?, Naunyn-Schmiedeberg's Archives of Pharmacology (2025)
10. Digging Deeper Through Glucose Metabolism and Its Regulators in Cancer and Metastasis, Life Sciences (2021)
11. Effect of Melatonin on Left Ventricular Function in Patients With Heart Failure, Journal of Isfahan Medical School (2011)
12. Effect of Melatonin Supplementation on Oxidative Stress Parameters: A Systematic Review and Meta-Analysis, Pharmacological Research (2020)
13. Effects of Melatonin Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Hormone and Metabolic Research (2019)
14. Effects of Melatonin on Left Ventricular Ejection Fraction and Functional Class of Patients With Heart Failure: A Randomized, Double-Blind, Placebocontrolled Trial, Journal of Research in Medical Sciences (2012)
15. The Protective Role of Melatonin in Cadmium-Induced Proliferation of Ovarian Cancer Cells, Research in Pharmaceutical Sciences (2018)
16. Melatonin Affects the Expression of Microrna-21: A Mini-Review of Current Evidence, Pathology Research and Practice (2024)
17. Therapeutic Effects of Melatonin on Endometriosis, Targeting Molecular Pathways: Current Knowledge and Future Perspective, Pathology Research and Practice (2023)
18. Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients With Primary Pneumosepsis: A Randomized Controlled Clinical Trial, Complementary Medicine Research (2022)
19. Melatonin Supplementation in Preclinical Colitis Models: A Systematic Review and Dose-Response Meta-Analysis on Inflammation, Oxidative Stress, and Colon Repair, PharmaNutrition (2024)
20. The Increment of Genoprotective Effect of Melatonin Due to “Autooptic” Effect Versus the Genotoxicity of Mitoxantrone, Journal of Biomedical Physics and Engineering (2020)
21. The Effect of Preoperative Melatonin on Nuclear Erythroid 2-Related Factor 2 Activation in Patients Undergoing Coronary Artery Bypass Grafting Surgery, Oxidative Medicine and Cellular Longevity (2013)
22. Melatonin Supplementation Improves N-Terminal Pro-B-Type Natriuretic Peptide Levels and Quality of Life in Patients With Heart Failure With Reduced Ejection Fraction: Results From Mehr Trial, a Randomized Clinical Trial, Clinical Cardiology (2022)
23. Melatonin in the Prevention of Cisplatin-Induced Acute Nephrotoxicity: A Randomized, Controlled Clinical Trial, Research in Pharmaceutical Sciences (2022)
24. Melatonin Aids in Treating Mood and Sleep Problems Resulting From Hormonal Therapy in Breast Cancer Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial, Iranian Journal of Pharmaceutical Research (2024)
25. Melatonin in the Management of Mood and Sleep Problems Induced by Androgen Deprivation Therapy in Prostate Cancer Patients: A Randomized Double-Blinded, Placebo-Controlled Clinical Trial, Iranian Journal of Pharmaceutical Research (2022)
26. Effect of Melatonin on Heart Failure: Design for a Double-Blinded Randomized Clinical Trial, ESC Heart Failure (2020)
27. Targeting Glioma Cells With Nutraceuticals: Therapeutic Effects Based on Molecular Mechanisms, New Evidence and Perspectives, Mini-Reviews in Medicinal Chemistry (2023)
28. Impact of Melatonin Supplementation on Glycemic Parameters in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis, Current Pharmaceutical Design (2025)