Therapeutic Effects of Melatonin on Endometriosis, Targeting Molecular Pathways: Current Knowledge and Future Perspective

Therapeutic Effects of Melatonin on Endometriosis, Targeting Molecular Pathways: Current Knowledge and Future Perspective Publisher Pubmed

Sharifi M¹ ; Rajabpoor Nikoo N² ; Badehnoosh B³ ; Shafabakhsh R⁴ ; Asemi R¹ ; Reiter RJ⁵ ; Asemi Z⁴

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1. Department of Internal Medicine, School of Medicine, Cancer Prevention Research Center, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
2. Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Gynecology and Obstetrics, Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran
4. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
5. Department of Cell Systems and Anatomy, UT Health. Long School of Medicine, San Antonio, TX, United States

Source: Pathology Research and Practice Published:2023

Abstract

Endometriosis, the very serious disease in women creates a huge financial burden worldwide, which is comparable to diabetes mellitus. In addition to the typical pelvic pain, endometriosis is related to low life quality and decreased work efficiency; clinical consequences include mood complaints, metabolic impairments, inflammation, immunologic problems, and elevated malignancy risks. Several risk factors are correlated with endometriosis including elevated oxidative and nitrosative stress, long-lasting inflammation, raised immune tolerance, as well as autoimmunity. Melatonin is a natural molecule present throughout both the plant and animal kingdoms. It has numerous functions as an antioxidant and anti‐inflammatory agent. Due to the anti-proliferative, antioxidant, anti-inflammatory, and anti-invasive features of melatonin, it performances as a beneficial agent to limit endometriosis; this involves several pathways including antiestrogenic, antioxidant, anti-inflammatory, and anti-apoptosis effects, as well as reducing the growth of E2-induced endometriotic tissue. Moreover, melatonin can favor sleep quality and decrease the unwanted signs in the patients. However, most of the data on melatonin accured from experimental works and additional clinical trials are needed. This review summarizes what is currently known regarding the influence of melatonin on endometriosis. Availability of data and material: Not applicable. © 2023 Elsevier GmbH

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Mehran Sharifi (5)

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Style	Citing Format
MLA	Sharifi M, et al.. "Therapeutic Effects of Melatonin on Endometriosis, Targeting Molecular Pathways: Current Knowledge and Future Perspective." Pathology Research and Practice, vol. 243, no. , 2023, pp. -.
APA	Sharifi M, Rajabpoor Nikoo N, Badehnoosh B, Shafabakhsh R, Asemi R, Reiter RJ, Asemi Z (2023). Therapeutic Effects of Melatonin on Endometriosis, Targeting Molecular Pathways: Current Knowledge and Future Perspective. Pathology Research and Practice, 243(), -.
Chicago	Sharifi M, Rajabpoor Nikoo N, Badehnoosh B, Shafabakhsh R, Asemi R, Reiter RJ, Asemi Z. "Therapeutic Effects of Melatonin on Endometriosis, Targeting Molecular Pathways: Current Knowledge and Future Perspective." Pathology Research and Practice 243, no. (2023): -.
Harvard	Sharifi M et al. (2023) 'Therapeutic Effects of Melatonin on Endometriosis, Targeting Molecular Pathways: Current Knowledge and Future Perspective', Pathology Research and Practice, 243(), pp. -.
Vancouver	Sharifi M, Rajabpoor Nikoo N, Badehnoosh B, Shafabakhsh R, Asemi R, Reiter RJ, et al.. Therapeutic Effects of Melatonin on Endometriosis, Targeting Molecular Pathways: Current Knowledge and Future Perspective. Pathology Research and Practice. 2023;243():-.
BibTex	@article{ author = {Sharifi M and Rajabpoor Nikoo N and Badehnoosh B and Shafabakhsh R and Asemi R and Reiter RJ and Asemi Z}, title = {Therapeutic Effects of Melatonin on Endometriosis, Targeting Molecular Pathways: Current Knowledge and Future Perspective}, journal = {Pathology Research and Practice}, volume = {243}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Sharifi M AU - Rajabpoor Nikoo N AU - Badehnoosh B AU - Shafabakhsh R AU - Asemi R AU - Reiter RJ AU - Asemi Z TI - Therapeutic Effects of Melatonin on Endometriosis, Targeting Molecular Pathways: Current Knowledge and Future Perspective JO - Pathology Research and Practice VL - 243 IS - SP - EP - PY - 2023 ER -

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