Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Association Between Neutrophil to Lymphocyte Ratio (Nlr) and the Extent of Coronary Artery Stenosis in Patients With Non-St Elevation-Acute Coronary Syndrome (Nste-Acs) Publisher



Soleimani A1 ; Aghazadehtabrizi N2 ; Pourmoghadas A3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan, Iran
  3. 3. Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2018


Abstract

Background: Cardiovascular diseases are the leading cause of mortality in Iran and in the world. Considering the importance of inflammation in atherosclerosis, studying inflammatory factors and their contribution to cardiovascular diseases is essential. Accordingly, this study evaluated the link between neutrophil to lymphocyte ratio (NLR) and coronary artery stenosis in patients undergoing coronary angiography. Methods: This cross-sectional study was performed on 372 patients under coronary angiography due to non-ST elevation-acute coronary syndrome (NSTE-ACS). In addition to demographic characteristics, neutrophil to lymphocyte ratio and the extent of coronary artery disease (CAD) were measured in patients. Chi-square and ANOVA tests were used to compare the data. Findings: There was a direct and significant association between neutrophil to lymphocyte ratio and the extent of coronary artery disease involvement (r = 0.125, P = 0.016). Moreover, by examining the diagnosis accuracy of the neutrophil to lymphocyte ratio in coronary artery disease, it was found that the best cut-off point was 2.4, the area under curve (ROC) was 0.69, with sensitivity of 72.4% and specificity of 58.3%. Conclusion: Neutrophil to lymphocyte ratio is directly and significantly associated to the extent of involvement of coronary arteries, and it can be used to predict the involvement and extent of coronary artery disease. © 2018, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Prognostic Impact of Monocyte-To-Lymphocyte Ratio in Coronary Heart Disease: A Systematic Review and Meta-Analysis, Journal of International Medical Research (2023)
2. The Neutrophil-To-Lymphocyte Ratio Predicts Cardiovascular Outcomes in Patients With Diabetes a Systematic Review and Meta-Analysis, Cardiology in Review (2024)
3. Association Between the Platelet-To-Lymphocyte Ratio and the No-Reflow Phenomenon and Thrombolysis in Myocardial Infarction Flow 3 After Primary Percutaneous Coronary Intervention in Patients With St-Segment Elevation Myocardial Infarction, Iranian Heart Journal (2017)
4. Effects of Cardiac Rehabilitation on Inflammatory Biomarkers in Unstable Ischemic Heart Disease Patients Following Percutaneous Coronary Intervention: A Randomized Controlled Study, Coronary artery disease (2024)
5. Rheumatoid Factor, Anti-Nuclear Antibody in Ischemic Heart Disease: Acute Versus Chronic Patients, ARYA Atherosclerosis (2014)
6. Neutrophil to Lymphocyte Ratio (Nlr) Prognostic Effects on Heart Failure; a Systematic Review and Meta-Analysis, BMC Cardiovascular Disorders (2023)
7. Evaluation of the Relationship Between Hematological Indices and Cardiovascular Events in Isfahan Cohort Study, Avicenna Journal of Clinical Medicine (2021)
8. Atherogenic Index of Plasma: A Valuable Novel Index to Distinguish Patients With Unstable Atherogenic Plaques, Journal of Research in Medical Sciences (2022)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (24)
Masoumeh Sadeghi (24)
Other Related Docs
9. The Role of Serum Levels of Microrna-21 and Matrix Metalloproteinase-9 in Patients With Acute Coronary Syndrome, Molecular and Cellular Biochemistry (2016)
10. Thrombotic Storm in Coronavirus Disease 2019: From Underlying Mechanisms to Its Management, Journal of Medical Microbiology (2022)
11. Is Helicobacter Pylori Infection a Risk Factor for Coronary Heart Disease?, ARYA Atherosclerosis (2012)
12. The Five-Year Trend of Coronary Artery Diseases Based on Angiography Results in Central Part of Iran, Iranian Heart Journal (2012)
13. Helicobacter Pylori Relation to Acute Myocardial Infarction in an Iranian Sample, Coronary Health Care (2001)
14. Elevated Plasma Myeloperoxidase Levels in Relation to Circulating Inflammatory Markers in Coronary Artery Disease, Biomarkers in Medicine (2011)
15. The Association Between Platelet-To-Lymphocyte Ratio With Mortality Among Patients Suffering From Acute Decompensated Heart Failure, BMC Cardiovascular Disorders (2021)
16. Is Impaired Fasting Glucose Associated With Increased Risk of Coronary Aterosclerosis?, Acta Medica Iranica (2008)
17. The Pattern of In-Hospital Mortality of Myocardial Infarction and Associated Factors in Iran: A National Study, Journal of Isfahan Medical School (2015)
18. Hematological Inflammatory Markers in Patients With Clinically Confirmed Familial Hypercholesterolemia, BioMed Research International (2022)
19. Epicardial Fat Thickness and Severity of Coronary Heart Disease in Patients With Diabetes Mellitus Type Ii, ARYA Atherosclerosis (2018)
20. Aspirin Resistance Status As Determined by Urinary Thromboxane B 2 (Txb2) Level in Patients With Ischemic Heart Disease and Its Relationship With Severity of Coronary Artery Disease, Journal of Isfahan Medical School (2011)
21. Is Lp(A), As Predictor of Severity of Coronary Artery Disease?, Journal of Isfahan Medical School (2009)
22. Increased Membrane Lipid Peroxidation and Decreased Na+/K+-Atpase Activity in Erythrocytes of Patients With Stable Coronary Artery Disease, Coronary Artery Disease (2015)
23. A Novel Inflammatory Signaling Pathway in Patients With Slow Coronary Flow: Nf-Κb/Il-1Β/Nitric Oxide, Cytokine (2021)
24. A Study on the Effect of Aspirin on Clinical Symptoms, Laboratory Indices, and Outcomes in Patients With Covid-19, Journal of Nephropharmacology (2023)
25. Evaluation of the Relationship of Neutrophil-To Lymphocyte Ratio and Platelet-To-Lymphocyte Ratio With In-Hospital Mortality in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Clinical Respiratory Journal (2021)
26. Interleukin-6 and E-Selectin in Acute Coronary Syndromes and Stable Angina Pectoris: A Comparative Study, Herz (2012)
27. Is Friedewald Formula a Good Estimation for Low Density Lipoprotein Level in Iranian Population?, Journal of Research in Medical Sciences (2012)
28. Evaluating the Relationship Between Rheumatic Valvular Heart Disease and Coronary Artery Diseases in Patient With Stable Angina in Isfahan City, Iran, Journal of Isfahan Medical School (2018)
29. Circulating C1q/Tnf-Related Protein-12 Levels Are Associated With the Severity of Coronary Artery Disease, Cytokine (2021)
30. Comparison of Epicardial Fat Thickness in Patients With Acute Coronary Syndrome or Chronic Stable Angina and Normal Individuals, Journal of Isfahan Medical School (2012)
31. Current Status of the Clinical Epidemiology of Myocardial Infarction in Men and Women: A National Cross-Sectional Study in Iran, International Journal of Preventive Medicine (2015)
32. The Correlation Between Early Complications of Percutaneous Coronary Intervention and High Sensitive C-Reactive Protein, ARYA Atherosclerosis (2013)
33. Heart Rate and Cardiovascular Events: A Nested Case-Control in Isfahan Cohort Study, Archives of Iranian Medicine (2014)
34. Analysis of Traditional Risk Factors on St-Segment Elevation Myocardial Infarction Characteristics; [بررسی عوامل خطر سنتی مرتبط با ویژگیهای بالینی بیماران انفارکتوس میوکارد با بالارونده قطعه St], Journal of Isfahan Medical School (2024)
35. Relationship Between Metabolic Syndrome and Angiographic Severity of Coronary Artery Disease, ARYA Atherosclerosis (2016)
36. Evaluation of the Coronary Angiography Results in Patients Referred to Cardiac Centers in Isfahan City, Iran, Journal of Isfahan Medical School (2017)
37. Decreased Na+/K+-Atpase Activity and Altered Susceptibility to Peroxidation and Lipid Composition in the Erythrocytes of Metabolic Syndrome Patients With Coronary Artery Disease, Annals of Nutrition and Metabolism (2019)
38. The Clinical Manifestation and Outcome of Covid-19 in Patients With a History of Ischemic Heart Disease; a Retrospective Case-Control Study, BMC Cardiovascular Disorders (2023)
39. Association Between Hdl Particles Size and Myeloperoxidase/ Paraoxonase-1 (Mpo/Pon1) Ratio in Patients With Acute Coronary Syndrome, Acta Medica Iranica (2013)
40. Can Icam and Vcam Can Predict Severity of Cad in Stable Angina?, Journal of Isfahan Medical School (2009)
41. Association Between Severity of Coronary Disease and Apolipoproteins a and B, Iranian Journal of Endocrinology and Metabolism (2011)
42. Prognostic Value of the High-Mobility Group Box-1 in Young Patients With Chest Pain, ARYA Atherosclerosis (2014)
43. The Role of Cytokine Profile and Lymphocyte Subsets in the Severity of Coronavirus Disease 2019 (Covid-19): A Systematic Review and Meta-Analysis, Life Sciences (2020)
44. Association of the Total Cholesterol Content of Erythrocyte Membranes With the Severity of Disease in Stable Coronary Artery Disease, Cholesterol (2014)
45. Evaluation of the Prognostic Value of Neutrophil‑To‑Lymphocyte Ratio and Platelet‑To‑Lymphocyte Ratio in Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Journal of Research in Medical Sciences (2022)
46. Evaluating the Impact of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention in Intermediate Coronary Artery Lesions on the Mode of Treatment and Their Outcomes: An Iranian Experie, ARYA Atherosclerosis (2015)
47. Cd4+Foxp3+ Treg and Its Icos+ Subsets in Patients With Myocardial Infarction, Iranian Journal of Immunology (2012)
48. Resistin and Prooxidant-Antioxidant Balance: Markers to Discriminate Acute Coronary Syndrome From Stable Angina, ARYA Atherosclerosis (2020)
49. Evaluation of Plasma Myeloperoxidase Levels in Patients With Premature Myocardial Infarction, Iranian Heart Journal (2014)
50. Survey of Coronary Catheterization Laboratory Activity in Iran During the Coronavirus Disease-2019 Pandemic, ARYA Atherosclerosis (2021)