Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Rheumatoid Factor, Anti-Nuclear Antibody in Ischemic Heart Disease: Acute Versus Chronic Patients



Sedaghat A1 ; Sadeghi M2 ; Heidari R3 ; Sistani E4 ; Bayanfar Z5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Science, Isfahan, Iran
  2. 2. Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Hypertension Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Isfahan University of Medical Science, Isfahan, Iran
  5. 5. Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: ARYA Atherosclerosis Published:2014

Abstract

BACKGROUND: Immunopathological and inflammatory processes play important roles in the initiation and development of ischemic heart disease. Hence, this study aimed to evaluate the relationship between serum levels rheumatoid factor (RF) and anti-nuclear antibodies (ANA) and severity of coronary stenotic lesions.; METHODS: Totally 140 patients with acute coronary syndrome (ACS) (n = 70) and chronic stable angina (CSA) (n = 70) that undergoing coronary angiography were enrolled in this study. ANA by the enzyme-linked immunosorbent assay(ELISA) and serum level of RF was measured by latex method. The severity of coronary stenotic lesions calculated by Gensini score. To analyze the correlations of ANA and RF to Gensini score Pearson correlation test was used. To adjust the effect of age and other confounder factors such hypertension, diabetes, hyperlipidemia and smoking multiple linear regression was used.; RESULTS: The mean serum levels of RF and ANA in CSA group were significantly higher than ACS group after adjusting for the confounder factors (P < 0.050 for ANA). Serum levels of ANA significantly correlated with severity of coronary stenotic lesions calculated by Gensini score (r = 0.40 and P < 0.050). After adjusting confounders, multiple linear regression analysis showed ANA remained independently associated with Gensini scores in ACS group (B = 0.505, P < 0.001).; CONCLUSION:Higher serum levels of ANA may be considered as independent risk factors for ACS. © 2014, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. The Five-Year Trend of Coronary Artery Diseases Based on Angiography Results in Central Part of Iran, Iranian Heart Journal (2012)
2. Prognostic Value of Infection and Inflammation Markers for Late Cardiac Events in an Iranian Sample, Eastern Mediterranean Health Journal (2008)
3. Investigating the Inflammatory Status in the Patients Candidate for Second Angiography After Coronary Stent Implantation, Acta Cardiologica (2023)
4. Serum Interleukin-18 and Extent of Coronary Artery Disease in Unstable Angina, ARYA Atherosclerosis (2018)
5. The Association Between Neutrophil to Lymphocyte Ratio (Nlr) and the Extent of Coronary Artery Stenosis in Patients With Non-St Elevation-Acute Coronary Syndrome (Nste-Acs), Journal of Isfahan Medical School (2018)
6. Can C-Reactive Protein and Fibrinogen Predict Major Adverse Cardiac Events in Cardiovascular and Cerebrovascular Patients?, Iranian Heart Journal (2015)
7. Circulating Levels of Calprotectin As a Biomarker in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis, Clinical Cardiology (2024)
8. High Sensitive C-Reactive Protein Serum Levels in Patients With Acute Coronary Syndrome, Journal of Isfahan Medical School (2012)
Experts (# of related papers)
View all Related Experts
Masoumeh Sadeghi (37)
Nizal Sarrafzadegan (34)
Other Related Docs
9. Can Icam and Vcam Can Predict Severity of Cad in Stable Angina?, Journal of Isfahan Medical School (2009)
10. Analysis of Traditional Risk Factors on St-Segment Elevation Myocardial Infarction Characteristics; [بررسی عوامل خطر سنتی مرتبط با ویژگیهای بالینی بیماران انفارکتوس میوکارد با بالارونده قطعه St], Journal of Isfahan Medical School (2024)
11. Circulating C1q/Tnf-Related Protein-12 Levels Are Associated With the Severity of Coronary Artery Disease, Cytokine (2021)
12. A Novel Inflammatory Signaling Pathway in Patients With Slow Coronary Flow: Nf-Κb/Il-1Β/Nitric Oxide, Cytokine (2021)
13. Association of High Level of Hs-Crp With In-Stent Restenosis: A Case-Control Study, Cardiovascular Revascularization Medicine (2019)
14. A Cardiovascular Risk Assessment Model According to Behavioral, Psychosocial and Traditional Factors in Patients With St-Segment Elevation Myocardial Infarction (Cras-Mi): Review of Literature and Methodology of a Multi-Center Cohort Study, Current Problems in Cardiology (2023)
15. Helicobacter Pylori Relation to Acute Myocardial Infarction in an Iranian Sample, Coronary Health Care (2001)
16. Is Subcutaneous Fat Tissue Associated With Coronary Artery Disease?, Iranian Journal of Endocrinology and Metabolism (2012)
17. Persian Registry of Cardiovascular Disease (Prove): Design and Methodology, ARYA Atherosclerosis (2017)
18. The Prevalence of Coronary Artery Disease in an Urban Population in Isfahan, Iran, Acta Cardiologica (1999)
19. Diagnostic Performance of 64-Row Coronary Ct Angiography in Detecting Significant Stenosis As Compared With Conventional Invasive Coronary Angiography, ARYA Atherosclerosis (2013)
20. Elevated Plasma Myeloperoxidase Levels in Relation to Circulating Inflammatory Markers in Coronary Artery Disease, Biomarkers in Medicine (2011)
21. Prevalence of Total Cholesterol in Iran: Systematic Review and Meta-Analysis, Journal of Mazandaran University of Medical Sciences (2015)
22. Is Impaired Fasting Glucose Associated With Increased Risk of Coronary Aterosclerosis?, Acta Medica Iranica (2008)
23. The Pattern of In-Hospital Mortality of Myocardial Infarction and Associated Factors in Iran: A National Study, Journal of Isfahan Medical School (2015)
24. The Correlation Between Coronary Artery Calcium Score With Diagnosis of Angina Pectoris in Patients With and Without Metabolic Syndrome, Candidates for Coronary Angiography; [ارتباط ًورُی کلسین شریاى کرًٍر در بیواراى با ٍ بذٍى سٌذرم هتابَلیک با تشخیص آًژیي صذری کاًذیذسیتی آًژیَگرافی کرًٍری], Journal of Isfahan Medical School (2022)
25. The Effect of Contrast Dye Injection and Balloon Inflation on Qtc and Qtc Dispersion in 12 Leads Surface Ekg During Ptca, ARYA Atherosclerosis (2011)
26. The Relationship Between Nut Consumption and Premature Coronary Artery Disease in a Representative Sample of Iranians: Iran-Premature Coronary Artery Disease (Ipad) Study, Public Health Nutrition (2023)
27. Coronary Artery Stenosis and Associations With Indicators of Anthropometric and Diet in Patients Undergoing Coronary Angiography, Journal of Diabetes and Metabolic Disorders (2018)
28. Epicardial Fat Thickness and Severity of Coronary Heart Disease in Patients With Diabetes Mellitus Type Ii, ARYA Atherosclerosis (2018)
29. Anti-Streptokinase Antibody Detection Before and Immediately After Streptokinase Therapy in Patients With Myocardial Infarction, Iranian Journal of Immunology (2006)
30. Aspirin Resistance Status As Determined by Urinary Thromboxane B 2 (Txb2) Level in Patients With Ischemic Heart Disease and Its Relationship With Severity of Coronary Artery Disease, Journal of Isfahan Medical School (2011)
31. Is Lp(A), As Predictor of Severity of Coronary Artery Disease?, Journal of Isfahan Medical School (2009)
32. Prognostic Impact of Monocyte-To-Lymphocyte Ratio in Coronary Heart Disease: A Systematic Review and Meta-Analysis, Journal of International Medical Research (2023)
33. Factor Analysis of Cardiovascular Risk Clustering in Pediatric Metabolic Syndrome: Caspian Study, Annals of Nutrition and Metabolism (2007)
34. A Study on the Effect of Aspirin on Clinical Symptoms, Laboratory Indices, and Outcomes in Patients With Covid-19, Journal of Nephropharmacology (2023)
35. Obstructive Sleep Apnea, Diagnosed by the Berlin Questionnaire and Association With Coronary Artery Disease Severity, ARYA Atherosclerosis (2015)
36. Correlation of Echocardiographic Epicardial Fat Thickness With Severity of Coronary Artery Disease-An Observational Study; [Koroner Arter Hastaliginin Siddeti Ile Ekokardiyografik Epikardiyal Yag Kalinliginin Iliskisi-Gozlemsel Bir Calisma], Anadolu Kardiyoloji Dergisi (2012)
37. Risk Factors, Clinical, and Laboratory Characteristics of Patients With a Diagnosis of Covid-19, Journal of Emergency Practice and Trauma (2022)
38. Association Between the Platelet-To-Lymphocyte Ratio and the No-Reflow Phenomenon and Thrombolysis in Myocardial Infarction Flow 3 After Primary Percutaneous Coronary Intervention in Patients With St-Segment Elevation Myocardial Infarction, Iranian Heart Journal (2017)
39. Interleukin-6 and E-Selectin in Acute Coronary Syndromes and Stable Angina Pectoris: A Comparative Study, Herz (2012)
40. Is Friedewald Formula a Good Estimation for Low Density Lipoprotein Level in Iranian Population?, Journal of Research in Medical Sciences (2012)
41. Evaluating the Relationship Between Rheumatic Valvular Heart Disease and Coronary Artery Diseases in Patient With Stable Angina in Isfahan City, Iran, Journal of Isfahan Medical School (2018)
42. Coronary Artery Calcification—Does It Predict the Cad-Rads Category?, Emergency Radiology (2022)
43. Correlation of Circulating Inflammatory Markers, Ghrelin, Adiponectin With Obesity Indices in Subjects With Metabolic Syndrome, Pakistan Journal of Medical Sciences (2013)
44. Prediction of Short-Term Clinical Outcome of Percutaneous Coronary Intervention in Patients With Acute Coronary Syndrome Through Myeloperoxidase Levels, ARYA Atherosclerosis (2014)
45. Factors Affecting Outcome of Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction, ARYA Atherosclerosis (2013)
46. Correlation Between Body Fat Distribution, Plasma Lipids and Apolipoproteins With the Severity of Coronary Involvement in Patients With Stable Angina, ARYA Atherosclerosis (2011)
47. Comparison of Epicardial Fat Thickness in Patients With Acute Coronary Syndrome or Chronic Stable Angina and Normal Individuals, Journal of Isfahan Medical School (2012)
48. Age at Menarche and Risk of Premature Coronary Artery Disease: Results From Iran Premature Coronary Disease (Ipad) Study, Archives of Gynecology and Obstetrics (2025)
49. The Thickness of the Intimal and Medial Layers of the Carotid Arteries, and the Index of Left Ventricular Mass, in Children of Patients With Premature Coronary Arterial Disease, Cardiology in the Young (2007)
50. Frequency of Atherosclerotic Lesions in Coronary Arteries of Autopsy Specimens in Isfahan Forensic Medicine Center, Journal of Research in Medical Sciences (2005)