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Increased Membrane Lipid Peroxidation and Decreased Na+/K+-Atpase Activity in Erythrocytes of Patients With Stable Coronary Artery Disease Publisher Pubmed



Namazi G1 ; Jamshidi Rad S2 ; Attar AM1 ; Sarrafzadegan N2 ; Sadeghi M3 ; Naderi G2 ; Pourfarzam M2
Authors
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Authors Affiliations
  1. 1. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, 81465-1148, Iran
  2. 2. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, 81465-1148, Iran
  3. 3. Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Coronary Artery Disease Published:2015


Abstract

Objectives We aimed to determine erythrocyte membrane lipid peroxidation levels and Na +/K +-ATPase activity in patients with and without coronary artery disease (CAD) documented by coronary angiography. Design and methods A total of 144 patients who had undergone coronary angiography were divided into a CAD group (n=82) and a non-CAD group (control group, n=62) according to the results of coronary angiography. Lipid peroxide levels in plasma and the erythrocyte membrane were measured using a fluorimetric method. Total antioxidant status and Na +/K +-ATPase activity in plasma were determined using spectrophotometric methods. Results Lipid peroxidation levels were significantly higher in the erythrocyte membrane of CAD patients compared with controls, whereas Na +/K +-ATPase activity was significantly lower in the erythrocyte membrane of CAD patients compared with controls. The coronary artery scores were correlated positively with membrane lipid peroxidation (r=0.324, P<0.001) and negatively with Na +/K +-ATPase activity (r=-0.302, P<0.001). Conclusion This study shows that the levels of membrane lipid peroxidation and Na +/K +-ATPase activity are correlated with the severity of CAD. © 2015 Wolters Kluwer Health, Inc.
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