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Novel Effects of Rosa Damascena Extract on Patients With Neurocognitive Disorder and Depression: A Clinical Trial Study Publisher



Esfandiary E1 ; Abdolali Z2 ; Omranifard V2 ; Ghanadian M3 ; Bagheriansararoud R2 ; Karimipour M4 ; Mahaki B5 ; Dabiri S6
Authors
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Authors Affiliations
  1. 1. Departments of Anatomical Sciences and Molecular, Biology Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Departments of Anatomical Sciences Tabriz, University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Pathology, School of Medicine, Kerman University of Medical Sciences, Isfahan, Iran

Source: International Journal of Preventive Medicine Published:2018


Abstract

Background: Dementia as a major cognitive neurological disorder is defined as impairment in one or more cognitive territories compared with the former level of performance. This disorder disrupts patient's independence, and the patient would need others aid in order of doing daily and complex activities. The aim of this study was to evaluate the efficacy of Rosa damascena extract in the improvement of cognitive function in patients with dementia. Methods: This study is a randomized double-blind, placebo-controlled clinical trial on 40 patients older than 55 years with dementia referred to Specialized Elderly Patients Clinic in 2015-2016. Patients were divided randomly into two groups (control and intervention). The intervention group used donepezil and R. damascena capsules, and in control group, placebo capsule instead of R. damascena added on donepezil. Four test was filled three times at the study initiation, after month one and also after month three: Mini-Mental State Examination (MMSE) and Addenbrooke's Cognitive Examination Revised (ACE-R) were used for cognition evaluation, for depression assessment, Geriatric Depression Scale was administered, and checklist of memory and behavioral disorders were filled. Results: The results showed add-on donepezil and R. damascena versus placebo improved cognitive impairment based on MMSE with P = 0.002, ACE-R with total P = 0.001, depression (P = 0.012), behavioral disorders (P < 0.001), and daily activity (P < 0.001). Conclusions: The R. damascena extract affected cognitive impairment of dementia patients significantly and also have significant effects on improving depression and behavioral problems. © 2018 International Journal of Preventive Medicine.
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