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Lipid-Based Nanodelivery Systems of Curcumin: Recent Advances, Approaches, and Applications Publisher Pubmed



Can Karaca A1 ; Rezaei A2, 3 ; Qamar M4 ; Assadpour E5, 6 ; Esatbeyoglu T7 ; Jafari SM8, 9
Authors
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Authors Affiliations
  1. 1. Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Istanbul, 34469, Turkiye
  2. 2. Department of Food Science and Technology, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Institute of Food Science and Nutrition, Bahauddin Zakariya University, Multan, 60800, Pakistan
  5. 5. Food Industry Research Co., Gorgan, Iran
  6. 6. Food and Bio-Nanotech International Research Center (Fabiano), Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran
  7. 7. Department of Molecular Food Chemistry and Food Development, Institute of Food and One Health, Gottfried Wilhelm Leibniz University Hannover, Am Kleinen Felde 30, Hannover, 30167, Germany
  8. 8. Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran
  9. 9. Halal Research Center of IRI, Iran Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran

Source: Food Chemistry Published:2025


Abstract

Despite its many beneficial effects, pharmaceutical applications of curcumin (CUR) are limited due to its chemical instability, low solubility/absorption and weak bioavailability. Recent advances in nanotechnology have enabled the development of CUR-loaded nanodelivery systems to tackle those issues. Within many different nanocarriers developed for CUR up to date, lipid-based nanocarriers (LBNs) are among the most extensively studied systems. LBNs such as nanoemulsions, solid lipid carriers, nanostructured phospholipid/surfactant carriers are shown to be potential delivery systems capable of improving the solubility, bioavailability, and chemical stability of CUR. The particle characteristics, stability, bioavailability, and release properties of CUR-loaded LBNs can be tailored via optimizing the formulation and processing parameters. This paper reviews the most recent studies on the development of various CUR-loaded LBNs. Approaches to the improvement of CUR bioavailability and release characteristics of LBNs are discussed. Furthermore, challenges in the development of CUR-loaded LBNs and their potential applications are presented. © 2024 Elsevier Ltd
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