In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Share this content! On (X network) By

In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs Publisher Pubmed

Badali H¹ ; Mohammadi R² ; Mashedi O³ ; De Hoog GS^{4, 5, 6, 7, 8, 9} ; Meis JF^{10, 11}

Show Affiliations

1. Department of Medical Mycology and Parasitology, Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
2. Department of Medical Parasitology and Mycology, Isfahan University of Medical Sciences, Isfahan, Iran
3. Kenya Medical Research Institute, Nairobi, Kenya
4. CBS-KNAW Fungal Biodiversity Centre, Utrecht, Netherlands
5. Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, Netherlands
6. Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
7. Peking University Health Science Center, Research Center for Medical Mycology, Beijing, China
8. Institute of Basic Biology, University of Parana, Curitiba, Brazil
9. King Abdulaziz University, Jeddah, Saudi Arabia
10. Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
11. Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, Netherlands

Source: Mycoses Published:2015

Abstract

Despite the common, worldwide, occurrence of dermatophytes, little information is available regarding susceptibility profiles against currently available and novel antifungal agents. A collection of sixty-eight clinical Trichophyton species and Epidermophyton floccosum were previously identified and verified to the species level by sequencing the internal transcribed spacer (ITS) regions of rDNA. MICs of amphotericin B, fluconazole, itraconazole, voriconazole, posaconazole, isavuconazole, terbinafine and MECs of caspofungin and anidulafungin were performed based on CLSI M38-A2. The resulting MIC90s of all strains were, in increasing order, as follows: terbinafine (0.063mgl-1); posaconazole (1mgl-1); isavuconazole and anidulafungin (2mgl-1); itraconazole, voriconazole, amphotericin B, and caspofungin (4mgl-1) and fluconazole (>64mgl-1). These results confirm that terbinafine is an excellent agent for treatment of dermatophytosis due to T. rubrum, T. mentagrophytes, T. verrucosum, T. schoenleinii and E. floccosum. In addition, the new azoles POS and ISA are potentially useful antifungals to treat dermatophytosis. However, the clinical effectiveness of these novel antifungals remains to be determined. © 2015 Blackwell Verlag GmbH.

Related Docs

View other Related Docs

1. Comparison of in Vitro Activities of Newer Triazoles and Classic Antifungal Agents Against Dermatophyte Species Isolated From Iranian University Hospitals: A Multi-Central Study, Annals of Clinical Microbiology and Antimicrobials (2023)

2. A Simple Multiplex Polymerase Chain Reaction Assay for Rapid Identification of the Common Pathogenic Dermatophytes: Trichophyton Interdigitale, Trichophyton Rubrum, and Epidermophyton Floccosum, Current Medical Mycology (2021)

3. Phylogenetic Analysis of Dermatophyte Species Using Dna Sequence Polymorphism in Calmodulin Gene, Medical Mycology (2016)

4. Antifungal Activity of a Novel Triazole, Efinaconazole and Nine Comparators Against 354 Molecularly Identified Aspergillus Isolates, Mycopathologia (2020)

5. In Vitro Activities of Five Antifungal Drugs Against Opportunistic Agents of Aspergillus Nigri Complex, Mycopathologia (2016)

6. A Molecular Epidemiological Survey of Clinically Important Dermatophytes in Iran Based on Specific Rflp Profiles of Beta-Tubulin Gene, Iranian Journal of Public Health (2013)

7. Iranian National Survey on Tinea Capitis: Antifungal Susceptibility Profile, Epidemiological Characteristics, and Report of Two Strains With a Novel Mutation in Sqle Gene With Homology Modeling, Mycopathologia (2023)

8. Frequency Distribution of Keratinophilic Dermatophyte Fungi From the Soil of Different Zones in Isfahan Using Morphological and Molecular Methods, Advanced Biomedical Research (2019)

Experts (# of related papers)

View all Related Experts

Rasoul Mohammadi (33)

Seyed Hossein Mirhendi Esfahani (24)

Other Related Docs

9. In Vitro Evaluation of Griseofulvin Against Clinical Isolates of Dermatophytes From Isfahan, Mycoses (2004)

10. Caspofungin-Non-Susceptible Candida Orthopsilosis Isolated From Onychomycosis in Iran, Iranian Journal of Public Health (2017)

11. Use of Restriction Fragment Length Polymorphism to Rapidly Identify Dermatophyte Species Related to Dermatophytosis, Jundishapur Journal of Microbiology (2015)

12. Differentiating Agents of Dermatophytosis (Trichophyton Rubrum and Trichophyton Interdigitale) in Human by Dual Polymerase Chain Reaction, Tehran University Medical Journal (2019)

13. Causative Agents of Onychomycosis: A 7-Year Study, Journal of Clinical Laboratory Analysis (2016)

14. Increasing and Alarming Prevalence of Trichophyton Indotineae As the Primary Causal Agent of Skin Dermatophytosis in Iran, Mycoses (2025)

15. An Investigation on Non-Invasive Fungal Sinusitis; Molecular Identification of Etiologic Agents, Journal of Research in Medical Sciences (2017)

16. Species Identification and in Vitro Antifungal Susceptibility Testing of Aspergillus Section Nigri Strains Isolated From Otomycosis Patients, Journal de Mycologie Medicale (2018)

17. Detection of Erg11 Point Mutations in Iranian Fluconazole-Resistant Candida Albicans Isolates, Current Medical Mycology (2019)

18. The First Case of Fingernail Onychomycosis Due to Neoscytalidium Novaehollandiae, Molecular Identification and Antifungal Susceptibility, Journal de Mycologie Medicale (2020)

19. Detection of Dermatophytes From Dermatophytosis-Suspected Cases in Iran, Evaluation of Polymerase Chain Reaction-Sequencing Method, Advanced Biomedical Research (2020)

20. A Fatal Case of Bloodstream Infection by Fusarium Solani in a Patient With Adrenocortical Carcinoma From Isfahan, Iran, International Journal of Cancer Management (2020)

21. An Alarming Rise of Non-Albicans Candida Species and Uncommon Yeasts in the Clinical Samples; a Combination of Various Molecular Techniques for Identification of Etiologic Agents, BMC Research Notes (2019)

22. Time and Cost-Efficient Identification of Trichophyton Indotineae, Mycoses (2023)

23. Identification of Dermatophyte and Nondermatophyte Molds Isolated From Animal Lesions Suspected to Dermatomycoses, Advanced Biomedical Research (2020)

24. A 10-Year Study of Dermatophytoses in Isfahan, Iran, Journal of Clinical Laboratory Analysis (2016)

25. In Vitro Activities of Six Antifungal Drugs Against Candida Glabrata Isolates: An Emerging Pathogen, Jundishapur Journal of Microbiology (2016)

26. Quantitative Analysis of Single-Nucleotide Polymorphism for Rapid Detection of Tr34/L98h- and Tr46/Y121f/T289a-Positive Aspergillus Fumigatus Isolates Obtained From Patients in Iran From 2010 to 2014, Antimicrobial Agents and Chemotherapy (2016)

27. Low Level of Antifungal Resistance in Iranian Isolates of Candida Glabrata Recovered From Blood Samples in a Multicenter Study From 2015 to 2018 and Potential Prognostic Values of Genotyping and Sequencing of Pdr1, Antimicrobial Agents and Chemotherapy (2019)

28. In Vitro Antifungal Susceptibility Profile of Iranian Fusarium Isolates: Emphasising on the Potent Inhibitory Effect of Efinaconazole Compared to Other Drugs, Mycoses (2023)

29. Amino Acid Substitutions in Erg11p of Azole-Resistant Candida Glabrata: Possible Effective Substitutions and Homology Modelling, Journal of Global Antimicrobial Resistance (2016)

30. Prevalence and Aetiology of Dermatophytoses in Isfahan, Iran, Mycoses (1997)

31. Epidemiology and Antifungal Susceptibility of Candida Species Isolated From 10 Tertiary Care Hospitals in Iran, Microbiology Spectrum (2022)

32. Development a Diagnostic Pan-Dermatophyte Taqman Probe Real-Time Pcr Assay Based on Beta Tubulin Gene, Mycoses (2016)

33. Diversity of Geophilic Dermatophytes Species in the Soils of Iran; the Significant Preponderance of Nannizzia Fulva, Journal of Fungi (2021)

34. The Epidemiology of Dermatophytosis Among Elementary School Children in Koohrang City, Iran, in 2014 and 2015, Journal of Isfahan Medical School (2015)

35. Epidemiologic and Antifungal Susceptibility Profile of Candiduria Among Patients Hospitalized in the Nephrology and Intensive Care Unit Wards, Tehran, Iran, Jundishapur Journal of Microbiology (2022)

36. Utilization of Size Polymorphism in Its1 and Its2 Regions for Identification of Pathogenic Yeast Species, Journal of Medical Microbiology (2017)

37. Sheep Serve As a Reservoir of Trichophyton Mentagrophytes Genotype V Infection, Medical Mycology (2023)

38. Direct Detection and Identification of the Most Common Bacteria and Fungi Causing Otitis Externa by a Stepwise Multiplex Pcr, Frontiers in Cellular and Infection Microbiology (2021)

39. Frequency of Uncommon Clinical Yeast Species Confirmed by Its-Sequencing, Archives of Clinical Infectious Diseases (2019)

40. Development and Evaluation of Sybr Green Real-Time Pcr for Rapid and Specific Identification of Trichophyton Indotineae, Mycoses (2025)

41. Safety and Efficacy of Terbinafine in a Pediatric Iranian Cohort of Patients With Tinea Capitis, Saudi Pharmaceutical Journal (2009)

42. Candida Palmioleophila Candidemia and Bacterial Co-Infection in a 3-Month-Old Infant With Biliary Atresia, Frontiers in Cellular and Infection Microbiology (2023)

43. Multicenter Identification and Antifungal Susceptibility Patterns of Candida Species Isolated From Clinical Samples, Jundishapur Journal of Microbiology (2017)

44. Otomycosis in Central Iran: A Clinical and Mycological Study, Iranian Red Crescent Medical Journal (2011)

45. In-Vivo Efficiency of the Novel Azole Compounds (Attaf-1 and Attaf-2) Against Systemic Candidiasis in a Murine Model, Journal of Medical Mycology (2023)

46. First Fatal Cerebral Phaeohyphomycosis Due to Rhinocladiella Mackenziei in Iran, Based on Its Rdna, Journal de Mycologie Medicale (2015)

47. Otomycosis Due to the Rare Fungi Talaromyces Purpurogenus, Naganishia Albida and Filobasidium Magnum, Mycopathologia (2020)

48. Study of Onychomycosis in Isfahan, Iran, Mycoses (2010)

49. In Vitro Antifungal Susceptibility Pattern of Candida Species Isolated From Gastroesophageal Candidiasis, Gastroenterology and Hepatology from Bed to Bench (2021)

50. A 3-Year Study of Candida Infections Among Patients With Malignancy: Etiologic Agents and Antifungal Susceptibility Profile, Frontiers in Cellular and Infection Microbiology (2023)

Style	Citing Format
MLA	Badali H, et al.. "In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs." Mycoses, vol. 58, no. 5, 2015, pp. 303-307.
APA	Badali H, Mohammadi R, Mashedi O, De Hoog GS, Meis JF (2015). In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs. Mycoses, 58(5), 303-307.
Chicago	Badali H, Mohammadi R, Mashedi O, De Hoog GS, Meis JF. "In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs." Mycoses 58, no. 5 (2015): 303-307.
Harvard	Badali H et al. (2015) 'In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs', Mycoses, 58(5), pp. 303-307.
Vancouver	Badali H, Mohammadi R, Mashedi O, De Hoog GS, Meis JF. In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs. Mycoses. 2015;58(5):303-307.
BibTex	@article{ author = {Badali H and Mohammadi R and Mashedi O and De Hoog GS and Meis JF}, title = {In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs}, journal = {Mycoses}, volume = {58}, number = {5}, pages = {303-307}, year = {2015} }
RIS	TY - JOUR AU - Badali H AU - Mohammadi R AU - Mashedi O AU - De Hoog GS AU - Meis JF TI - In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs JO - Mycoses VL - 58 IS - 5 SP - 303 EP - 307 PY - 2015 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract