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Gd and Zn Co-Substituted Magnetite Nanoparticles As High T2 Mri Agents Publisher



Behshid B1 ; Ahmad K1 ; Hojjat SA2 ; Sabino VV3 ; Jesus RC4 ; Del Puerto MM3 ; Morteza M5
Authors
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Authors Affiliations
  1. 1. Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran
  2. 2. School of Pharmacy, Isfahan Pharmaceutical Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Instituto de Ciencia de Materiales de Madrid, CSIC, Cantoblanco, Madrid 28049, Spain
  4. 4. Instituto de Estudios Biofuncionales, Centro de Investigacion Biomodica en Red de Enfermedades Respiratorias (CIBERES), Universidad Complutense, Madrid 28040, Spain
  5. 5. Physics Department, Razi University, Kermanshah, Iran

Source: IFMBE Proceedings Published:2011


Abstract

Monodispersed aqueous ferrofluids of superparamagnetic Gd substituted Zn-Fe ferrite (Fe0.7 Zn0.3 Gdy Fe2-y O4, y=0, 0.01, 0.025, 0.04 and 0.05) nanoparticles were synthesized via a direct, efficient and environmental friendly citric acid assisted hydrothermal method. Synthesized nanoparticles were characterized by X Ray Powder Diffraction (XRD), Fourier Transform Infrared (FTIR) spectroscopy, Transmission Electron Microscopy (TEM), Dynamic Light Scattering (DLS) method. Ferrofluids obtained by this way showed good stability at pH=7 and hydrodynamic sizes lower than 100 nm with polydispersity indexes below 0.2 at high concentrations (>25 mg/ml). Longitudinal (r1) and transverse (r2) relaxivities were measured at 1.5 T and 37°C. The results showed that the substitution of Gd in the structure of Zn-Fe ferrite has a strong effect on the transverse (r2) relaxivity, increasing its value up to 400 s-1. mM-1. © 2011 Springer-Verlag Berlin Heidelberg.