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Effects of Some Parameters on Particle Size Distribution of Chitosan Nanoparticles Prepared by Ionic Gelation Method Publisher



Vaezifar S1 ; Razavi S2 ; Golozar MA1 ; Karbasi S3 ; Morshed M4 ; Kamali M5
Authors
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Authors Affiliations
  1. 1. Department of Materials Engineering, Isfahan University of Technology, 84156-83111 Isfahan, Iran
  2. 2. Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, 81744-176 Isfahan, Iran
  3. 3. Medical Physics and Biomedical Engineering Group, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Textile Engineering, Isfahan University of Technology, 84156-83111 Isfahan, Iran
  5. 5. Chemical Process Research Group, Institute of Process Engineering, Faculty of Engineering, University of Isfahan, 81746-73441 Isfahan, Iran

Source: Journal of Cluster Science Published:2013


Abstract

In this research, chitosan nanoparticles were prepared based on the ionic gelation of chitosan with tripolyphosphate anions. Effects of parameters such as chitosan concentration, tripolyphosphate concentration, and reaction time on the particle size distribution were investigated. In order to determine optimum conditions, tests were designed by Qualitek-4 software, using Taguchi method. The best conditions were determined based on three factors at three levels. Therefore, the main object was to investigate the effect of some parameters on particle size distribution and determine the optimum conditions for preparing chitosan nanoparticles by ionic gelation, followed by evaluation of the physicochemical and structural properties. The size distribution of original chitosan and chitosan nanoparticles were determined by Laser Diffraction and Dynamic Light Scattering, respectively. The physicochemical properties of the chitosan nanoparticles were studied using SEM, TEM, XRD pattern, FTIR, UV-vis, TGA, and NMR spectra. The optimum chitosan concentration, tripolyphosphate concentration, and reaction time were found to be 1.0 mg/ml, 1.0 mg/ml, and 60 min, respectively. © 2013 Springer Science+Business Media New York.
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