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Covalent Triazine-Based Polyimine Framework As a Biocompatible Ph-Dependent Sustained-Release Nanocarrier for Sorafenib: An in Vitro Approach Publisher



Mokhtari N1 ; Taymouri S2 ; Mirian M3 ; Dinari M1
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  2. 2. Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Molecular Liquids Published:2020


Abstract

In the present study, a novel polyimine-based covalent triazine framework (PI-CTF) was introduced as a promising biocompatible carrier for sorafenib (SFN) delivery. High specific surface area and porosity allowed us to achieve drug loading and encapsulation efficiency as high as 83% and 98%, respectively. The in vitro drug release study of SFN-loaded PI-CTF showed a sustained and pH-dependent release behavior in which acidic pH accelerated drug release compared with the neutral pH. Notably, cytotoxicity assay against L929 cells revealed the safety and biocompatibility of PI-CTF. Moreover, MTT assay against LNCaP prostate cancer cells expressed that the anticancer activity of SFN had no diminution after incorporating into PI-CTF. Thus, PI-CTF has envisaged as a great promise toward anti-cancer drug carrier. © 2019 Elsevier B.V.
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