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Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells Publisher



Nasehi N1 ; Varshosaz J1 ; Taymouri S1 ; Rostami M2 ; Akbari V3 ; Firoozpour L4
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Medicinal Chemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pharmaceutical Biotechnology, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2020


Abstract

In present study, sorafenib loaded nanomicelles were prepared with synthesized pluronic F127 - lithocholic acid by film hydration method. The optimized micelles were spherical showing particle size of 319.36 nm, zeta potential of -11.96 mV, encapsulation efficiency of 87.31%, loading efficiency of 14.87% and release efficiency of 30.1%. Sorafenib loaded nanomicelles showed negligible hemolysis activity on RBC, indicating excellent hemocompatibility of pluronic F127 - lithocholic acid. The drug free nanomicelles showed no cytotoxicity against L929 cells by using MTT assay. However, micellar sorafenib showed more anti-proliferation effect on LNCaP and DU145 cells as compared with free sorafenib. © 2019, © 2019 Taylor & Francis Group, LLC.
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