Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells

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Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells Publisher

Summary: A study found drug-loaded nanomicelles kill cancer cells better with fewer side effects. #CancerResearch #Nanotechnology

Nasehi N¹ ; Varshosaz J¹ ; Taymouri S¹ ; Rostami M² ; Akbari V³ ; Firoozpour L⁴

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2020

Abstract

In present study, sorafenib loaded nanomicelles were prepared with synthesized pluronic F127 - lithocholic acid by film hydration method. The optimized micelles were spherical showing particle size of 319.36 nm, zeta potential of -11.96 mV, encapsulation efficiency of 87.31%, loading efficiency of 14.87% and release efficiency of 30.1%. Sorafenib loaded nanomicelles showed negligible hemolysis activity on RBC, indicating excellent hemocompatibility of pluronic F127 - lithocholic acid. The drug free nanomicelles showed no cytotoxicity against L929 cells by using MTT assay. However, micellar sorafenib showed more anti-proliferation effect on LNCaP and DU145 cells as compared with free sorafenib. © 2019, © 2019 Taylor & Francis Group, LLC.

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Style	Citing Format
MLA	Nasehi N, et al.. "Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells." International Journal of Polymeric Materials and Polymeric Biomaterials, vol. 69, no. 3, 2020, pp. 158-172.
APA	Nasehi N, Varshosaz J, Taymouri S, Rostami M, Akbari V, Firoozpour L (2020). Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells. International Journal of Polymeric Materials and Polymeric Biomaterials, 69(3), 158-172.
Chicago	Nasehi N, Varshosaz J, Taymouri S, Rostami M, Akbari V, Firoozpour L. "Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells." International Journal of Polymeric Materials and Polymeric Biomaterials 69, no. 3 (2020): 158-172.
Harvard	Nasehi N et al. (2020) 'Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells', International Journal of Polymeric Materials and Polymeric Biomaterials, 69(3), pp. 158-172.
Vancouver	Nasehi N, Varshosaz J, Taymouri S, Rostami M, Akbari V, Firoozpour L. Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells. International Journal of Polymeric Materials and Polymeric Biomaterials. 2020;69(3):158-172.
BibTex	@article{ author = {Nasehi N and Varshosaz J and Taymouri S and Rostami M and Akbari V and Firoozpour L}, title = {Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells}, journal = {International Journal of Polymeric Materials and Polymeric Biomaterials}, volume = {69}, number = {3}, pages = {158-172}, year = {2020} }
RIS	TY - JOUR AU - Nasehi N AU - Varshosaz J AU - Taymouri S AU - Rostami M AU - Akbari V AU - Firoozpour L TI - Sorafenib Loaded Pluronic F127-Lithocholic Acid Micelles for Prostate Cancer Therapy: Formulation, Optimization, and in Vitro Evaluation Against Lncap Cells JO - International Journal of Polymeric Materials and Polymeric Biomaterials VL - 69 IS - 3 SP - 158 EP - 172 PY - 2020 ER -

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