Isfahan University of Medical Sciences

Science Communicator Platform

Share By
Triglyceride Glucose-Waist Circumference As a Predictor of Mortality and Subtypes of Cardiovascular Disease: A Systematic Review and Meta-Analysis Publisher

Summary: Meta-analysis shows TyG-waist circumference predicts higher risk of cardiovascular diseases and mortality. #CardiovascularHealth #TyGWC

Rabiee Rad M1 ; Ghasempour Dabaghi G1 ; Sadri H2 ; Darouei B3 ; Amanibeni R3 ; Mazaheritehrani S4
Authors

Source: Diabetology and Metabolic Syndrome Published:2025


Abstract

Background: The significant burden of cardiovascular diseases underscores the necessity for identifying novel predictive markers that can forecast both cardiovascular diseases and mortality. In recent years, TyG-obesity-related parameters have gained special attention in this regard. This study aimed to assess the association between TyG-waist circumference (TyG-WC) and cardiovascular diseases and mortality. Methods: A comprehensive search was performed in databases including PubMed, Scopus, and Web of Science from their inception until October 6, 2024. The key outcomes of interest included all-cause mortality, cardiovascular mortality, cardiovascular diseases, myocardial infarction, stroke, coronary artery diseases, peripheral artery diseases, and heart failure. The pooled risk ratio (RR) with corresponding 95% confidence intervals (CI) was calculated. Meta-analysis was carried out using StataMP 14.0. Results: A total of 17 studies were included in the analysis. The number of participants ranged between 2,224 and 95,342. The meta-analysis revealed that TyG-WC is significantly associated with an increased risk of all-cause mortality, cardiovascular mortality, cardiovascular diseases, myocardial infarction, stroke, coronary artery diseases, and peripheral artery diseases. However, only one study addressed the relationship between TyG-WC and heart failure with a positive correlation. Conclusion: This study indicates that TyG-WC could serve as a promising predictor of cardiovascular diseases, along with cardiovascular and all-cause mortality. Given its accessibility, TyG-WC may be a practical tool for screening purposes. © The Author(s) 2025.
Related Docs
View other Related Docs
1. Association of the Triglyceride Glucose Index As a Measure of Insulin Resistance With Mortality and Cardiovascular Disease in Populations From Five Continents (Pure Study): A Prospective Cohort Study, The Lancet Healthy Longevity (2023)
2. Association of the Triglyceride Glucose Index With All-Cause and Cardiovascular Mortality in a General Population of Iranian Adults, Cardiovascular Diabetology (2024)
3. The Association Between Triglyceride-Glucose Index and Contrast-Induced Nephropathy; a Systematic Review and Meta-Analysis, Journal of Nephropharmacology (2025)
Experts (# of related papers)
View all Related Experts
Masoumeh Sadeghi (4)
Jamshid Najafian (2)
Triglyceride Glucose-Waist Circumference As a Predictor of Mortality and Subtypes of Cardiovascular Disease: A Systematic Review and Meta-Analysis
Other Related Docs
4. Intensive Blood Pressure Control in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Cardiovascular and Microvascular Outcomes, American Journal of Hypertension (2026)
5. The Neutrophil-To-Lymphocyte Ratio Predicts Cardiovascular Outcomes in Patients With Diabetes a Systematic Review and Meta-Analysis, Cardiology in Review (2024)
6. Association of Triglyceride Glucose-Body Mass Index (Tyg-Bmi) With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Meta-Analysis, PLOS ONE (2025)
7. Association of Triglyceride Glucose Index With Cardiovascular Events: Insights From the Isfahan Cohort Study (Ics), European Journal of Medical Research (2024)
8. Association Between Body Composition Indices and Vascular Health: A Systematic Review and Meta-Analysis, Eating and Weight Disorders (2025)
9. The Effect of Red Pepper/Capsaicin on Cardiovascular Risk Factors: A Systematic Review, Meta-Analysis, and Grade Assessment, Nutrition, Metabolism and Cardiovascular Diseases (2026)
10. Efficacy of Orlistat for the Treatment of Metabolic Dysfunction–Associated Steatotic Liver Disease Patients: A Systematic Review and Meta-Analysis, Hepatology Forum (2025)
11. The Prognostic Role of Glycemic Variability in Predicting the Risk of Adverse Cardiovascular Events in Patients With Cardiovascular Diseases: A Meta-Analysis, Diabetology and Metabolic Syndrome (2025)
12. Investigating the Association Between Triglyceride-Glucose Index and Risk of Chronic Kidney Disease: A Systematic Review and Meta-Analysis, Clinical Nutrition ESPEN (2025)
13. Effect of Long-Term Oxygen Therapy on Reducing Rehospitalization of Patients With Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis, Pulmonary Therapy (2023)
14. Cardiovascular and Mortality Outcomes of Dpp-4 Inhibitors Vs. Sulfonylureas As Metformin Add-On Therapy in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis, PLOS ONE (2025)
15. Mean Serum Lipid Levels in Iranian Adult Populations: A Systematic Review and Meta-Analysis, Clinical Lipidology (2015)
16. Comparison Between European and Iranian Cutoff Points of Triglyceride/High-Density Lipoprotein Cholesterol Concentrations in Predicting Cardiovascular Disease Outcomes, Journal of Clinical Lipidology (2016)
17. Effect of Green Tea Extract on Lipid Profile in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2020)
18. The Negative Impact of Obesity on the Occurrence and Prognosis of the 2019 Novel Coronavirus (Covid-19) Disease: A Systematic Review and Meta-Analysis, Eating and Weight Disorders (2022)
19. The Effect of Nettle (Urtica Dioica) Supplementation on the Glycemic Control of Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis, Phytotherapy Research (2020)
20. Predictors of Mortality for Patients With St-Elevation Myocardial Infraction After 2-Year Follow-Up: A St-Elevation Myocardial Infarction Cohort in Isfahan Study, Advanced Biomedical Research (2022)