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The First Cut-Off Points for Generalized and Abdominal Obesity in Predicting Lipid Disorders in a Nationally Representative Population in the Middle East: The National Survey of Risk Factors for Non-Communicable Diseases of Iran



Delavari A1 ; Kelishadi R2 ; Forouzanfar MH3 ; Safaei A4 ; Birjandi F5 ; Alikhani S6
Authors
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Authors Affiliations
  1. 1. Endocrine and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. National Health Laboratory, Ministry of Health and Medical Education, Tehran, Iran
  5. 5. National Blood Transfusion Organization, Tehran, Iran
  6. 6. Applied Research Coordination Council, Ministry of Health and Medical Education, Tehran, Iran

Source: Archives of Medical Science Published:2009

Abstract

Introduction: To determine the prevalence of dyslipidaemia and the optimal cut-off points of body mass index (BMI) and waist circumference (WC) at which abnormal lipid levels can be identified with maximum sensitivity and specificity in a nationwide population-based sample for the first time in the Middle East. Material and methods: Using a probability proportional to size, multistage cluster sampling method, a sociodemographically representative sample of 3024 of the Iranian population aged 25-64 years living in urban and rural areas of all 30 provinces of the country was studied. Results: The mean age of participants was 41.3 (0.07) years. The receiver operating curve (ROC) analysis showed that the optimal cut-off value of BMI to identify with maximum sensitivity and specificity the detection of lipid disorders was 25 kg/m2 for males and 26-28 kg/m2 for females. Considering WC, among males this optimal cut-off value was 88-89 cm for high total cholesterol (T. Chol), low HDL-C and high triglycerides (TG), whereas it was lower (86 cm) for predicting high LDL-C. Among females, this cut-off value was 83-84 cm for predicting high T. Chol, high LDL-C and high TG, but it was higher (90 cm) for low HDL-C. The most prevalent type of abnormal lipid level was low HDL-C. Conclusions: The optimal cut-off points provided in the current study might serve as a public health action threshold in the Middle East population. The very high prevalence of high TG and low HDL-C suggest that current guidelines for screening lipid disorders that are based on total and LDL cholesterol should consider such ethnic differences. Copyright © 2009 Termedia & Banach.
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