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Peptide-Functionalized Polymeric Nanoparticles for Delivery of Curcumin to Cancer Cells Publisher



Rostami N1 ; Ghebleh A2 ; Noei H3 ; Rizi ZS4 ; Moeinzadeh A5 ; Nikzad A6 ; Gomari MM7 ; Uversky VN8 ; Tarighi P7
Authors
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Authors Affiliations
  1. 1. Department of Chemical Engineering, Arak University, Arak, 3848177584, Iran
  2. 2. School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  3. 3. Department of Medical Biology and Genetics, Faculty of Medicine, Istinye University, Istanbul, 34010, Turkey
  4. 4. Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, 1417935840, Iran
  5. 5. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, 1449614535, Iran
  6. 6. Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, 08854, NJ, United States
  7. 7. Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, 1449614535, Iran
  8. 8. Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, 33612, FL, United States

Source: Journal of Drug Delivery Science and Technology Published:2024


Abstract

Polymeric nanoparticles (NPs) have garnered significant interest due to their potential in drug delivery. Specifically, nanopolymers functionalized with molecules such as proteins or peptides serve as versatile vehicles for this purpose. Curcumin (Cur) is a widely studied anticancer compound known for its positive effects on human health. Nevertheless, its insolubility and low bio-distribution hinder the exploitation of its beneficial traits. In this study, our team developed a nanodelivery system using a nanopolymer called poly(ε-caprolactone)-poly(ethylene glycol) (PCL-PEG), functionalized with A6 peptide to enable targeted delivery of Cur. The designed system exhibited favorable characteristics, including a stable zeta potential of −13.8 mV, a small size of 76.4 nm, uniform surface morphology, and high hydrophilicity with a contact angle of 31.53°. Additionally, the targeted delivery system demonstrated high encapsulation efficiency (EE%) (93 ± 0.89 %), drug loading (DL%) (16.7 ± 0.9 %), and a slow and gradual release profile with a release of approximately 83.1 ± 0.12 %. The MTT assay results showed significant cell death in MDA-MB-231 cancer cells (IC50 = 21.3 ± 1.57 μM) when treated with the Cur-NPs-A6 formulation, while the toxicity of the designed NPs was reduced on non-cancerous MCF-10A cells. Moreover, both the RT-qPCR and invasion assays demonstrated the system's effectiveness in activating apoptosis pathways and inhibiting cell invasion. These findings suggest that the engineered intelligent delivery system, equipped with the A6 peptide, which has a strong affinity for CD44 (a protein with increased expression in malignancy), could be an exceptionally effective strategy for cancer treatment. © 2024 Elsevier B.V.
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