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Evaluation of Multilayer Coated Magnetic Nanoparticles As Biocompatible Curcumin Delivery Platforms for Breast Cancer Treatment Publisher



Akrami M1 ; Khoobi M2, 3 ; Khalilvandsedagheh M2 ; Haririan I1, 3 ; Bahador A4 ; Faramarzi MA5 ; Rezaei S5 ; Javar HA1 ; Salehi F6 ; Ardestani SK5, 6 ; Shafiee A2
Authors
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Authors Affiliations
  1. 1. Department, Of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran
  3. 3. Medical Biomaterials Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Biotechnology Research Center, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, 14176, Iran
  6. 6. Institute of Biochemistry and Biophysics, Department of Biochemistry, University of Tehran, Tehran, Iran

Source: RSC Advances Published:2015


Abstract

Biocompatible multi-layer iron oxide magnetic nanoparticles (MNPs) for drug delivery applications with increased loading capacity, sustained sensitive release profile, and high inherent magnetic properties as well as improved cellular uptake were prepared. In this approach, Fe3O4 MNPs were obtained by a co-precipitation method and functionalized using hydroxyapatite (HAP) and/or polyethyleneimine (PEI). They were then modified with β-cyclodextrin (CD) to increase their loading capacity. These MNPs allowed suitable encapsulation of hydrophobic curcumin (CUR) in the CD shell and CUR adsorption into the polymeric layers. The dissolution profile of CUR showed pH sensitive release of CUR. The protein corona pattern of the MNPs by electrophoresis showed lower protein adsorption for CD modified MNPs than for other MNPs. No significant toxicity was observed for the target MNPs, whereas the CUR loaded MNPs inhibited MCF-7 breast cancer cells more efficiently than free CUR. Moreover, the negligible hemolytic activity of the target MNPs showed their excellent haemocompatibility for cancer treatment. The preferential uptake of the drug by MCF-7 cells was observed for CUR loaded MNPs in comparison with free CUR using flow cytometric analysis. As a result, the designed and prepared MNPs can be considered to be a promising CUR delivery platform. © 2015 The Royal Society of Chemistry.