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Folic Acid-Adorned Curcumin-Loaded Iron Oxide Nanoparticles for Cervical Cancer Publisher Pubmed



Ramezani Farani M1 ; Azarian M2 ; Heydari Sheikh Hossein H3 ; Abdolvahabi Z4 ; Mohammadi Abgarmi Z5 ; Moradi A6 ; Mousavi SM7 ; Ashrafizadeh M8, 9 ; Makvandi P10 ; Saeb MR11 ; Rabiee N12, 13
Authors
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Authors Affiliations
  1. 1. Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Radiology, Charite - Universitatsmedizin Berlin, Chariteplatz 1, Berlin, 10117, Germany
  3. 3. Department of Biotechnology, Faculty of Biological Sciences and Technology, University of Isfahan, Isfahan, 81746-73441, Iran
  4. 4. Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, 241567, Iran
  5. 5. Department of Clinical Biochemistry, Faculty of Medical Science, Tarbiat Modares University, P.O. Box: 14115-331, Tehran, Iran
  6. 6. Department of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, P.O. Box: 14956-161, Tehran, Iran
  7. 7. School of Medicine, Bam University of Medical Sciences, Bam, Iran
  8. 8. Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Universite Caddesi No. 27, Orhanll, Istanbul, Tuzla, 34956, Turkey
  9. 9. Sabanci University Nanotechnology Research and Application Center (SUNUM), Istanbul, Tuzla, 34956, Turkey
  10. 10. Istituto Italiano di Tecnologia, Centre for Materials Interfaces, viale Rinaldo Piaggio 34, Pisa, Pontedera, 56025, Italy
  11. 11. Department of Polymer Technology, Faculty of Chemistry, Gdansk University of Technology, G. Narutowicza 11/12 80-233, Gdansk, 80-233, Poland
  12. 12. Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran, Iran
  13. 13. School of Engineering, Macquarie University, Sydney, 2109, NSW, Australia

Source: ACS Applied Bio Materials Published:2022


Abstract

Cancer is a deadly disease that has long plagued humans and has become more prevalent in recent years. The common treatment modalities for this disease have always faced many problems and complications, and this has led to the discovery of strategies for cancer diagnosis and treatment. The use of magnetic nanoparticles in the past two decades has had a significant impact on this. One of the objectives of the present study is to introduce the special properties of these nanoparticles and how they are structured to load and transport drugs to tumors. In this study, iron oxide (Fe3O4) nanoparticles with 6 nm sizes were coated with hyperbranched polyglycerol (HPG) and folic acid (FA). The functionalized nanoparticles (10-20 nm) were less likely to aggregate compared to non-functionalized nanoparticles. HPG@Fe3O4and FA@HPG@Fe3O4nanoparticles were compared in drug loading procedures with curcumin. HPG@Fe3O4and FA@HPG@Fe3O4nanoparticles' maximal drug-loading capacities were determined to be 82 and 88%, respectively. HeLa cells and mouse L929 fibroblasts treated with nanoparticles took up more FA@HPG@Fe3O4nanoparticles than HPG@Fe3O4nanoparticles. The FA@HPG@Fe3O4nanoparticles produced in the current investigation have potential as anticancer drug delivery systems. For the purpose of diagnosis, incubation of HeLa cells with nanoparticles decreased MRI signal enhancement's percentage and the largest alteration was observed after incubation with FA@HPG@Fe3O4nanoparticles. © 2022 American Chemical Society. All rights reserved.
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