Ph-Responsive Carbon Nanotube-Based Hybrid Nanogels As the Smart Anticancer Drug Carrier Publisher Pubmed



Seyfoori A^{1, 2} ; Sarfarazijami S¹ ; Seyyed Ebrahimi SA¹
Source: Artificial Cells# Nanomedicine and Biotechnology Published:2019

Abstract

Tumour drug delivery using nanocarriers is attracting ample attentions due to their high drug-loading capacity. Regarding specific tumour microenvironment properties as acidic pH, smart nanocarriers with the ability of responding to the microenvironment, can have a profound effect on the level of drug release and subsequent tumour treatment. In this study, by combining the advantages of multiwall carbon nanotube and pH-sensitive nanogels, multifunctional magneto/pH-responsive nano-hybrid system is developed to deliver the doxorubicin as a general cancer chemotherapeutic drug. The chemical and physical properties of the nanocarrier, as well as drug-loading efficiency and drug releasing characteristics were analysed. It was showed functionalized CNT has low pH-responsiveness in acidic environment, whereas chitosan-coated magnetic nanocomposite can result in greater pH-responsiveness and subsequently higher drug release over a week compared to nanocomposite system without chitosan. This behaviour was proved in Live/Dead assay of the U-87 glioblastoma cell lines exposed to DOX release supernatant at different time intervals so that significant effect of DOX supernatant on cancer cell proliferation suppression was showed. © 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.