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Preventive Impact of Probiotic Supplements on Heart Injury and Inflammatory Indices in a Rat Model of Myocardial Infarction: Histopathological and Gene Expression Evaluation Publisher



Bonab SF1, 2 ; Tahmasebi S3, 4 ; Ghafourifard S5 ; Eslami S6, 7
Authors
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Authors Affiliations
  1. 1. Department of Medical laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Faculty of Converging Sciences and Technologies, Science and Research Branch, Photonic, Biology and Cognitive Science Research Center, Islamic Azad University, Tehran, Iran
  4. 4. Department of Biology, Faculty of Science, Arak Branch, Islamic Azad University, Arak, Iran
  5. 5. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran
  7. 7. Department of Medical Biotechnology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

Source: APMIS Published:2025


Abstract

Although there is a bulk of evidence on the favorable effect of probiotics on the cardiac system, their role in the management of myocardial infarction is not clear. Three viable probiotic bacterial strains, namely Lactobacillus reuteri, Bifidobacterium longum, and Bifidobacterium lactis, were gavaged to the rats daily for 28 days prior to the induction of myocardial injury. Myocardial injury was induced by the use of isoproterenol (ISO) in the probiotics, control and sham groups. The heart tissues were catheterized to evaluate the histopathological parameters and measure the expression of genes related to inflammation. Treatment with ISO caused subendocardial necrosis and rupture of cardiac myofibrils. Pretreatment with probiotics reduced the size of myocardial infarction caused by ISO. Also, in the probiotic group, a relative decrease in the amount of tissue fibrosis and rupture of cardiomyocytes fibers was seen. Pretreatment with probiotics partially ameliorated myocardial necrosis, edema and leukocyte infiltration. Also, a remarkable decrease was detected in the expression of tissue proinflammatory genes in the pretreated group with probiotics. Thus, viable probiotic supplementation may ameliorate or prevent cardiac injury. Additional preclinical and clinical studies are required to clarify the impact of probiotics in the prevention and management of cardiovascular disease. © 2024 Scandinavian Societies for Pathology, Medical Microbiology and Immunology.
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