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Targeting Epigenetics in Cancer: Therapeutic Potential of Flavonoids Publisher Pubmed



Khan H1 ; Belwal T2 ; Efferth T3 ; Farooqi AA4 ; Sanchessilva A5, 6 ; Vacca RA7 ; Nabavi SF8 ; Khan F9 ; Prasad Devkota H10 ; Barreca D11 ; Sureda A12 ; Tejada S13 ; Dacrema M14 ; Daglia M14, 21 Show All Authors
Authors
  1. Khan H1
  2. Belwal T2
  3. Efferth T3
  4. Farooqi AA4
  5. Sanchessilva A5, 6
  6. Vacca RA7
  7. Nabavi SF8
  8. Khan F9
  9. Prasad Devkota H10
  10. Barreca D11
  11. Sureda A12
  12. Tejada S13
  13. Dacrema M14
  14. Daglia M14, 21
  15. Suntar I15
  16. Xu S16, 22
  17. Ullah H1
  18. Battino M17, 18, 19
  19. Giampieri F17, 18, 20
  20. Nabavi SM8
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan
  2. 2. College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, China
  3. 3. Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany
  4. 4. Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore, Pakistan
  5. 5. National Institute for Agricultural and Veterinary Research (INIAV), Porto, Portugal
  6. 6. Center for Study in Animal Science (CECA), ICETA, University of Porto, Porto, Portugal
  7. 7. Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Council of Research, Bari, Italy
  8. 8. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  9. 9. Department of Toxicology and Pharmacology, The Institute of Pharmaceutical Sciences (TIPS), School of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
  11. 11. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
  12. 12. Research Group on Community Nutrition and Oxidative Stress (NUCOX), Health Research Institute of the Balearic Islands (IdISBa), CIBEROBN (Physiopathology of Obesity and Nutrition), University of Balearic Islands, Palma de Mallorca, Balearic Islands, Spain
  13. 13. Laboratory of neurophysiology, Biology Department, Health Research Institute of the Balearic Islands (IdISBa), CIBEROBN (Physiopathology of Obesity and Nutrition), University of the Balearic Islands, Palma de Mallorca, Spain
  14. 14. Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Pavia, Italy
  15. 15. Deparment of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, Ankara, Turkey
  16. 16. Aab Cardiovascular Research Institute, University of Rochester, Rochester, NY, United States
  17. 17. Nutrition and Food Science Group, Department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo, Vigo Campus, Vigo, Spain
  18. 18. Department of Clinical Sciences, Universita Politecnica delle Marche, Ancona, Italy
  19. 19. International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, China
  20. 20. College of Food Science and Technology, Northwest University, Xi’an, Shaanxi, China
  21. 21. Department of Pharmacy, University of Naples Federico II, Naples, Italy
  22. 22. Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China

Source: Critical Reviews in Food Science and Nutrition Published:2021


Abstract

Irrespective of sex and age, cancer is the leading cause of mortality around the globe. Therapeutic incompliance, unwanted effects, and economic burdens imparted by cancer treatments, are primary health challenges. The heritable features in gene expression that are propagated through cell division and contribute to cellular identity without a change in DNA sequence are considered epigenetic characteristics and agents that could interfere with these features and are regarded as potential therapeutic targets. The genetic modification accounts for the recurrence and uncontrolled changes in the physiology of cancer cells. This review focuses on plant-derived flavonoids as a therapeutic tool for cancer, attributed to their ability for epigenetic regulation of cancer pathogenesis. The epigenetic mechanisms of various classes of flavonoids including flavonols, flavones, isoflavones, flavanones, flavan-3-ols, and anthocyanidins, such as cyanidin, delphinidin, and pelargonidin, are discussed. The outstanding results of preclinical studies encourage researchers to design several clinical trials on various flavonoids to ascertain their clinical strength in the treatment of different cancers. The results of such studies will define the clinical fate of these agents in future. © 2020 Taylor & Francis Group, LLC.
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